2-(2-(3-(3-hydroxy-(2R)-methylpropyl)-2-methoxymethoxymethylene-(6R)-methylcyclohex-(1S)-yl)ethyl)-2-methyl-1,3-dioxolane

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Chemical Name:2-(2-(3-(3-hydroxy-(2R)-methylpropyl)-2-methoxymethoxymethylene-(6R)-methylcyclohex-(1S)-yl)ethyl)-2-methyl-1,3-dioxolane
CAS No.:141039-66-9
Molecular Formula:C₁₉H₃₄O₅
Molecular Weight:342.476
Hs Code.:

Synonyms:2-(2-(3-(3-hydroxy-(2R)-methylpropyl)-2-methoxymethoxymethylene-(6R)-methylcyclohex-(1S)-yl)ethyl)-2-methyl-1,3-dioxolane

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Chemical Property of 2-(2-(3-(3-hydroxy-(2R)-methylpropyl)-2-methoxymethoxymethylene-(6R)-methylcyclohex-(1S)-yl)ethyl)-2-methyl-1,3-dioxolane

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Technology Process of 2-(2-(3-(3-hydroxy-(2R)-methylpropyl)-2-methoxymethoxymethylene-(6R)-methylcyclohex-(1S)-yl)ethyl)-2-methyl-1,3-dioxolane

There total 8 articles about 2-(2-(3-(3-hydroxy-(2R)-methylpropyl)-2-methoxymethoxymethylene-(6R)-methylcyclohex-(1S)-yl)ethyl)-2-methyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 141039-67-0
2-(2-(3-((2R)-methoxymethylcarbonylpropyl)-2-methoxymethyloxymethylene-(6R)-methylcyclohex-(1S)-yl)ethyl)-2-methyl-1,3-dioxolane

: 141039-66-9
2-(2-(3-(3-hydroxy-(2R)-methylpropyl)-2-methoxymethoxymethylene-(6R)-methylcyclohex-(1S)-yl)ethyl)-2-methyl-1,3-dioxolane

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether;
DOI:10.1016/S0040-4039(00)91851-3

Reference yield:

: 50906-56-4
(1R,5S,8R,9S,12R,14R)-8,12-dimethyl-4-methylidene-2,13-dioxatetracyclo[7.5.0.0^1,5.0^12,14]tetradecan-3-one

: 141039-66-9
2-(2-(3-(3-hydroxy-(2R)-methylpropyl)-2-methoxymethoxymethylene-(6R)-methylcyclohex-(1S)-yl)ethyl)-2-methyl-1,3-dioxolane

Guidance literature:: Multi-step reaction with 6 steps

1.1: 57 percent / hydrogen / tris(triphenylphosphine)rhodium(I) chloride / benzene; ethanol

2.1: 59 percent / WCl₆; n-BuLi / tetrahydrofuran / 1.75 h / 20 °C

3.1: ozone / CH₂Cl₂; methanol / -78 - 20 °C

3.2: 93 percent / dimethyl sulfide / CH₂Cl₂; methanol / 3 h / 20 °C

4.1: 96 percent / trimethylsilyl triflate / CH₂Cl₂ / 16 h / -78 °C

5.1: sodium naphthalenide / tetrahydrofuran / -25 °C

5.2: 82 percent / triethylamine / tetrahydrofuran / 4 h / -25 - 20 °C

6.1: 90 percent / LiAlH₄ / diethyl ether / 1 h / -78 °C

With lithium aluminium tetrahydride; n-butyllithium; trimethylsilyl trifluoromethanesulfonate; hydrogen; sodium naphthalenide; tungsten(VI) chloride; ozone; Wilkinson's catalyst; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; benzene; 1.1: Hydrogenation / 2.1: deoxygenation / 3.1: ozonolysis / 3.2: Reduction / 4.1: ketalization / 5.1: Reduction / 5.2: Alkylation / 6.1: Reduction;
DOI:10.1016/S0040-4020(97)10286-1

Reference yield:

: 87206-33-5
(3R)-dihydroarteannuin B

: 141039-66-9
2-(2-(3-(3-hydroxy-(2R)-methylpropyl)-2-methoxymethoxymethylene-(6R)-methylcyclohex-(1S)-yl)ethyl)-2-methyl-1,3-dioxolane

Guidance literature:: Multi-step reaction with 5 steps

1.1: 59 percent / WCl₆; n-BuLi / tetrahydrofuran / 1.75 h / 20 °C

2.1: ozone / CH₂Cl₂; methanol / -78 - 20 °C

2.2: 93 percent / dimethyl sulfide / CH₂Cl₂; methanol / 3 h / 20 °C

3.1: 96 percent / trimethylsilyl triflate / CH₂Cl₂ / 16 h / -78 °C

4.1: sodium naphthalenide / tetrahydrofuran / -25 °C

4.2: 82 percent / triethylamine / tetrahydrofuran / 4 h / -25 - 20 °C

5.1: 90 percent / LiAlH₄ / diethyl ether / 1 h / -78 °C

With lithium aluminium tetrahydride; n-butyllithium; trimethylsilyl trifluoromethanesulfonate; sodium naphthalenide; tungsten(VI) chloride; ozone; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1.1: deoxygenation / 2.1: ozonolysis / 2.2: Reduction / 3.1: ketalization / 4.1: Reduction / 4.2: Alkylation / 5.1: Reduction;
DOI:10.1016/S0040-4020(97)10286-1