dimethyl (1R,2r,3S,4s)-2,4-diphenylcyclobutane-1,3-dicarboxylate

Base Information

• Chemical Name: dimethyl (1R,2r,3S,4s)-2,4-diphenylcyclobutane-1,3-dicarboxylate
• CAS No.: 112530-30-0
• Molecular Formula: C₂₀H₂₀O₄
• Molecular Weight: 324.376
• Mol file: 112530-30-0.mol

Synonyms:dimethyl (1R,2r,3S,4s)-2,4-diphenylcyclobutane-1,3-dicarboxylate

Chemical Property of dimethyl (1R,2r,3S,4s)-2,4-diphenylcyclobutane-1,3-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl (1R,2r,3S,4s)-2,4-diphenylcyclobutane-1,3-dicarboxylate

There total 21 articles about dimethyl (1R,2r,3S,4s)-2,4-diphenylcyclobutane-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(2SR,3RS,4SR,5RS)-2,4-dimethyl 3,5-diphenylpyrrolidine-2,4-dicarboxylate (113273-67-9) → dimethyl (1R,2r,3S,4s)-2,4-diphenylcyclobutane-1,3-dicarboxylate (112530-30-0)

Guidance literature:

With [hydroxy(tosyloxy)iodo]benzene; ammonium carbamate; In 2,2,2-trifluoroethanol; at 80 ℃; for 2h; stereospecific reaction;

DOI:10.1021/jacs.1c10175

Reference yield:

methyl (2Z)-3-phenylprop-2-enoate (19713-73-6,1754-62-7) → dimethyl 2,4-diphenylcyclobutane-1,3-dicarboxylate (56586-34-6) + dimethyl (1R,2r,3S,4s)-2,4-diphenylcyclobutane-1,3-dicarboxylate (112530-30-0) + peritruxillic acid dimethyl ester (112530-29-7) + dimethyl (1R,2S,4S)-3,4-diphenylcyclobutane-1,2-dicarboxylate (36650-44-9)

Guidance literature:

boron trifluoride diethyl etherate; In dichloromethane; for 30h; Further byproducts given; Irradiation;

DOI:10.1021/ja00212a039

Reference yield:

methyl (2Z)-3-phenylprop-2-enoate (19713-73-6,1754-62-7) → dimethyl 2,4-diphenylcyclobutane-1,3-dicarboxylate (56586-34-6) + dimethyl (1R,2r,3S,4s)-2,4-diphenylcyclobutane-1,3-dicarboxylate (112530-30-0) + peritruxillic acid dimethyl ester (112530-29-7) + ζ-truxinic acid dimethyl ester (36650-44-9,52305-38-1,52305-39-2,57287-73-7,57287-74-8,58691-75-1,58691-76-2,64666-08-6,64666-09-7,64666-10-0,114180-12-0)

Guidance literature:

boron trifluoride diethyl etherate; In dichloromethane; for 30h; Further byproducts given; Irradiation;

DOI:10.1021/ja00212a039

upstream raw materials:

diazomethane

methyl (2Z)-3-phenylprop-2-enoate

methyl 2-(benzylideneamino)acetate

methyl cinnamate

Downstream raw materials:

2,4-diphenyl-cyclobutane-1,3-dicarboxylic acid monomethyl ester