(2SR,3RS,4SR,5RS)-2,4-dimethyl 3,5-diphenylpyrrolidine-2,4-dicarboxylate

Base Information

Chemical Name:(2SR,3RS,4SR,5RS)-2,4-dimethyl 3,5-diphenylpyrrolidine-2,4-dicarboxylate
CAS No.:113273-67-9
Molecular Formula:C₂₀H₂₁NO₄
Molecular Weight:339.391
Hs Code.:

Synonyms:(2SR,3RS,4SR,5RS)-2,4-dimethyl 3,5-diphenylpyrrolidine-2,4-dicarboxylate

Suppliers and Price of (2SR,3RS,4SR,5RS)-2,4-dimethyl 3,5-diphenylpyrrolidine-2,4-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2SR,3RS,4SR,5RS)-2,4-dimethyl 3,5-diphenylpyrrolidine-2,4-dicarboxylate

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Technology Process of (2SR,3RS,4SR,5RS)-2,4-dimethyl 3,5-diphenylpyrrolidine-2,4-dicarboxylate

There total 4 articles about (2SR,3RS,4SR,5RS)-2,4-dimethyl 3,5-diphenylpyrrolidine-2,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 66646-88-6
methyl 2-(benzylideneamino)acetate

: 103-26-4,1754-62-7
methyl cinnamate

: 113273-67-9
(2SR,3RS,4SR,5RS)-2,4-dimethyl 3,5-diphenylpyrrolidine-2,4-dicarboxylate

Guidance literature:: With rac-TF-BiphamPhos; silver(I) acetate; potassium carbonate; In dichloromethane; at 20 ℃; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja2043563

Reference yield: 77.0%

: 66646-88-6
methyl 2-(benzylideneamino)acetate

: 103-26-4,1754-62-7
Methyl cinnamate

: 113273-67-9
(2SR,3RS,4SR,5RS)-2,4-dimethyl 3,5-diphenylpyrrolidine-2,4-dicarboxylate

Guidance literature:: With triethylamine; lithium bromide; In tetrahydrofuran; for 22h; Ambient temperature;
DOI:10.1021/jo00242a008

Reference yield:

: 100-52-7
benzaldehyde

: 113273-67-9
(2SR,3RS,4SR,5RS)-2,4-dimethyl 3,5-diphenylpyrrolidine-2,4-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / benzene / 1 h / Heating

2: 77 percent / LiBr, Et₃N / tetrahydrofuran / 22 h / Ambient temperature

With triethylamine; lithium bromide; In tetrahydrofuran; benzene;
DOI:10.1021/jo00242a008