1,1,1,3,3,3-hexafluoro-2-(4-((2S)-2-(tetrahydro-2H-pyran-4-ylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

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Chemical Name:1,1,1,3,3,3-hexafluoro-2-(4-((2S)-2-(tetrahydro-2H-pyran-4-ylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol
CAS No.:1361216-60-5
Molecular Formula:C₂₃H₂₆F₆N₂O₄S₂
Molecular Weight:572.593
Hs Code.:

Synonyms:1,1,1,3,3,3-hexafluoro-2-(4-((2S)-2-(tetrahydro-2H-pyran-4-ylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

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Chemical Property of 1,1,1,3,3,3-hexafluoro-2-(4-((2S)-2-(tetrahydro-2H-pyran-4-ylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

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Technology Process of 1,1,1,3,3,3-hexafluoro-2-(4-((2S)-2-(tetrahydro-2H-pyran-4-ylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

There total 9 articles about 1,1,1,3,3,3-hexafluoro-2-(4-((2S)-2-(tetrahydro-2H-pyran-4-ylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

: 2402-72-4
2-(4-bromophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

: 1534361-95-9
(3S)-3-(tetrahydro-(2H)-pyran-4-yl-methyl)-1-(2-thiophenylsulfonyl)piperazine

: 1361216-60-5
1,1,1,3,3,3-hexafluoro-2-(4-((2S)-2-(tetrahydro-2H-pyran-4-ylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; ruphos; at 100 ℃; Heating; Sealed tube;
DOI:10.1021/jm4016735

Reference yield:

: 50675-18-8
3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde

: 1361216-60-5
1,1,1,3,3,3-hexafluoro-2-(4-((2S)-2-(tetrahydro-2H-pyran-4-ylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

Guidance literature:: Multi-step reaction with 9 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; (Rc,Sp)-Duanphos / methanol / 3 h / 20 °C / 3345.86 Torr / Inert atmosphere

3.1: lithium hydroxide; water / tetrahydrofuran; water / 20 °C / pH 3 / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

4.2: 20 °C

5.1: lithium hydroxide / dichloromethane; trifluoroacetic acid / 20 °C

5.2: 4 h / 20 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Reflux

7.1: hydrogenchloride / 1,4-dioxane

8.1: triethylamine / dichloromethane / 20 °C

9.1: sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos / 100 °C / Heating; Sealed tube

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; (Rc,Sp)-Duanphos; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; sodium t-butanolate; ruphos; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.1021/jm4016735

Reference yield:

: 1361215-57-7
methyl N-(tert-butoxycarbonyl)-3-(tetrahydro-2H-pyran-4-yl)-L-alaninate

: 1361216-60-5
1,1,1,3,3,3-hexafluoro-2-(4-((2S)-2-(tetrahydro-2H-pyran-4-ylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hydroxide; water / tetrahydrofuran; water / 20 °C / pH 3 / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

2.2: 20 °C

3.1: lithium hydroxide / dichloromethane; trifluoroacetic acid / 20 °C

3.2: 4 h / 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Reflux

5.1: hydrogenchloride / 1,4-dioxane

6.1: triethylamine / dichloromethane / 20 °C

7.1: sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos / 100 °C / Heating; Sealed tube

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; water; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; sodium t-butanolate; ruphos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.1021/jm4016735