(-)-triisopropyl{4-[1-({2-[({(1S)-1-methyl-3-[4-(4-propylcyclohexyl)phenyl]-2-propynyl}oxy)methyl]-1-naphthyl}ethynyl)-2-naphthyl]-1-butynyl}silane

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Chemical Name:(-)-triisopropyl{4-[1-({2-[({(1S)-1-methyl-3-[4-(4-propylcyclohexyl)phenyl]-2-propynyl}oxy)methyl]-1-naphthyl}ethynyl)-2-naphthyl]-1-butynyl}silane
CAS No.:861105-58-0
Molecular Formula:C₅₅H₆₄OSi
Molecular Weight:769.198
Hs Code.:

Synonyms:(-)-triisopropyl{4-[1-({2-[({(1S)-1-methyl-3-[4-(4-propylcyclohexyl)phenyl]-2-propynyl}oxy)methyl]-1-naphthyl}ethynyl)-2-naphthyl]-1-butynyl}silane

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Chemical Property of (-)-triisopropyl{4-[1-({2-[({(1S)-1-methyl-3-[4-(4-propylcyclohexyl)phenyl]-2-propynyl}oxy)methyl]-1-naphthyl}ethynyl)-2-naphthyl]-1-butynyl}silane

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Technology Process of (-)-triisopropyl{4-[1-({2-[({(1S)-1-methyl-3-[4-(4-propylcyclohexyl)phenyl]-2-propynyl}oxy)methyl]-1-naphthyl}ethynyl)-2-naphthyl]-1-butynyl}silane

There total 4 articles about (-)-triisopropyl{4-[1-({2-[({(1S)-1-methyl-3-[4-(4-propylcyclohexyl)phenyl]-2-propynyl}oxy)methyl]-1-naphthyl}ethynyl)-2-naphthyl]-1-butynyl}silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 861105-57-9
(-)-1-iodo-2-[({(1S)-1-methyl-3-[4-(4-propylcyclohexyl)phenyl]-2-propynyl}oxy)methyl]naphthalene

: 566912-09-2
[4-(1-ethynylnaphthalen-2-yl)but-1-yn-1-yl][tri(propan-2-yl)]silane

: 861105-58-0
(-)-triisopropyl{4-[1-({2-[({(1S)-1-methyl-3-[4-(4-propylcyclohexyl)phenyl]-2-propynyl}oxy)methyl]-1-naphthyl}ethynyl)-2-naphthyl]-1-butynyl}silane

Guidance literature:: With copper(l) iodide; diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 20 ℃; for 2h;
DOI:10.1021/ol047311p

Reference yield:

: 860639-66-3,111158-11-3
1-iodo-4-(4-propyl-cyclohexyl)-benzene

: 861105-58-0
(-)-triisopropyl{4-[1-({2-[({(1S)-1-methyl-3-[4-(4-propylcyclohexyl)phenyl]-2-propynyl}oxy)methyl]-1-naphthyl}ethynyl)-2-naphthyl]-1-butynyl}silane

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / CuI; PPh₃; iPr₂NH / Pd(CH₃CN)2Cl₂ / toluene / 1.5 h / 0 - 20 °C

2: 97 percent / KH / tetrahydrofuran / 0.5 h / 0 - 20 °C

3: 80 percent / CuI; iPr₂NH / Pd(PPh₃)4 / 2 h / 20 °C

With copper(l) iodide; potassium hydride; diisopropylamine; triphenylphosphine; dichloro bis(acetonitrile) palladium(II); tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; toluene;
DOI:10.1021/ol047311p

Reference yield:

: 861105-56-8
(2S)-(-)-4-[4-(4-propylcyclohexyl)phenyl]-3-butyn-2-ol

: 861105-58-0
(-)-triisopropyl{4-[1-({2-[({(1S)-1-methyl-3-[4-(4-propylcyclohexyl)phenyl]-2-propynyl}oxy)methyl]-1-naphthyl}ethynyl)-2-naphthyl]-1-butynyl}silane

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / KH / tetrahydrofuran / 0.5 h / 0 - 20 °C

2: 80 percent / CuI; iPr₂NH / Pd(PPh₃)4 / 2 h / 20 °C

With copper(l) iodide; potassium hydride; diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran;
DOI:10.1021/ol047311p