(-)-1-{[2-(3-butynyl)-1-nephthyl]ethynyl}-2-[({(1S)-1-methyl-3-[4-(4-propylcyclohexyl)phenyl]-2-propynyl}oxy)methyl]naphthalene

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Chemical Name:(-)-1-{[2-(3-butynyl)-1-nephthyl]ethynyl}-2-[({(1S)-1-methyl-3-[4-(4-propylcyclohexyl)phenyl]-2-propynyl}oxy)methyl]naphthalene
CAS No.:861105-59-1
Molecular Formula:C₄₆H₄₄O
Molecular Weight:612.855
Hs Code.:

Synonyms:(-)-1-{[2-(3-butynyl)-1-nephthyl]ethynyl}-2-[({(1S)-1-methyl-3-[4-(4-propylcyclohexyl)phenyl]-2-propynyl}oxy)methyl]naphthalene

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Chemical Property of (-)-1-{[2-(3-butynyl)-1-nephthyl]ethynyl}-2-[({(1S)-1-methyl-3-[4-(4-propylcyclohexyl)phenyl]-2-propynyl}oxy)methyl]naphthalene

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Technology Process of (-)-1-{[2-(3-butynyl)-1-nephthyl]ethynyl}-2-[({(1S)-1-methyl-3-[4-(4-propylcyclohexyl)phenyl]-2-propynyl}oxy)methyl]naphthalene

There total 5 articles about (-)-1-{[2-(3-butynyl)-1-nephthyl]ethynyl}-2-[({(1S)-1-methyl-3-[4-(4-propylcyclohexyl)phenyl]-2-propynyl}oxy)methyl]naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 861105-58-0
(-)-triisopropyl{4-[1-({2-[({(1S)-1-methyl-3-[4-(4-propylcyclohexyl)phenyl]-2-propynyl}oxy)methyl]-1-naphthyl}ethynyl)-2-naphthyl]-1-butynyl}silane

: 861105-59-1
(-)-1-{[2-(3-butynyl)-1-nephthyl]ethynyl}-2-[({(1S)-1-methyl-3-[4-(4-propylcyclohexyl)phenyl]-2-propynyl}oxy)methyl]naphthalene

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/ol047311p

Reference yield:

: 860639-66-3,111158-11-3
1-iodo-4-(4-propyl-cyclohexyl)-benzene

: 861105-59-1
(-)-1-{[2-(3-butynyl)-1-nephthyl]ethynyl}-2-[({(1S)-1-methyl-3-[4-(4-propylcyclohexyl)phenyl]-2-propynyl}oxy)methyl]naphthalene

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / CuI; PPh₃; iPr₂NH / Pd(CH₃CN)2Cl₂ / toluene / 1.5 h / 0 - 20 °C

2: 97 percent / KH / tetrahydrofuran / 0.5 h / 0 - 20 °C

3: 80 percent / CuI; iPr₂NH / Pd(PPh₃)4 / 2 h / 20 °C

4: 92 percent / nBu₄NF / tetrahydrofuran / 2 h / 20 °C

With copper(l) iodide; tetrabutyl ammonium fluoride; potassium hydride; diisopropylamine; triphenylphosphine; dichloro bis(acetonitrile) palladium(II); tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; toluene;
DOI:10.1021/ol047311p

Reference yield:

: 861105-56-8
(2S)-(-)-4-[4-(4-propylcyclohexyl)phenyl]-3-butyn-2-ol

: 861105-59-1
(-)-1-{[2-(3-butynyl)-1-nephthyl]ethynyl}-2-[({(1S)-1-methyl-3-[4-(4-propylcyclohexyl)phenyl]-2-propynyl}oxy)methyl]naphthalene

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / KH / tetrahydrofuran / 0.5 h / 0 - 20 °C

2: 80 percent / CuI; iPr₂NH / Pd(PPh₃)4 / 2 h / 20 °C

3: 92 percent / nBu₄NF / tetrahydrofuran / 2 h / 20 °C

With copper(l) iodide; tetrabutyl ammonium fluoride; potassium hydride; diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran;
DOI:10.1021/ol047311p