(1S,2R)-2-[(tert-butyldiphenylsilyloxy)methyl]-1-[(S)-1-hydroxy-3-methylbutyl]cyclopropane

Base Information

• Chemical Name: (1S,2R)-2-[(tert-butyldiphenylsilyloxy)methyl]-1-[(S)-1-hydroxy-3-methylbutyl]cyclopropane
• CAS No.: 534585-24-5
• Molecular Formula: C₂₅H₃₆O₂Si
• Molecular Weight: 396.645
• Mol file: 534585-24-5.mol

Synonyms:(1S,2R)-2-[(tert-butyldiphenylsilyloxy)methyl]-1-[(S)-1-hydroxy-3-methylbutyl]cyclopropane

Chemical Property of (1S,2R)-2-[(tert-butyldiphenylsilyloxy)methyl]-1-[(S)-1-hydroxy-3-methylbutyl]cyclopropane

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (1S,2R)-2-[(tert-butyldiphenylsilyloxy)methyl]-1-[(S)-1-hydroxy-3-methylbutyl]cyclopropane

There total 1 articles about (1S,2R)-2-[(tert-butyldiphenylsilyloxy)methyl]-1-[(S)-1-hydroxy-3-methylbutyl]cyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isobutylmagnesium bromide (926-62-5) + (1S,2R)-2-(tert-butyldiphenylsilyloxy)methyl-1-formylcyclopropane (408348-34-5) → (1S,2R)-2-[(tert-butyldiphenylsilyloxy)methyl]-1-[(R)-1-hydroxy-3-methylbutyl]cyclopropane + (1S,2R)-2-[(tert-butyldiphenylsilyloxy)methyl]-1-[(S)-1-hydroxy-3-methylbutyl]cyclopropane (534585-24-5)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1021/jo030019v

Reference yield: 98.0%

(S)-Mosher acid (17257-71-5,20445-31-2,56135-03-6,81655-41-6) + (1S,2R)-2-[(tert-butyldiphenylsilyloxy)methyl]-1-[(S)-1-hydroxy-3-methylbutyl]cyclopropane (534585-24-5) → (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-1-[(1S,2R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-cyclopropyl]-3-methyl-butyl ester

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jo030019v

Reference yield: 97.0%

R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid (20445-31-2) + (1S,2R)-2-[(tert-butyldiphenylsilyloxy)methyl]-1-[(S)-1-hydroxy-3-methylbutyl]cyclopropane (534585-24-5) → (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-1-[(1S,2R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-cyclopropyl]-3-methyl-butyl ester

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jo030019v

upstream raw materials:

isobutylmagnesium bromide

(1S,2R)-2-(tert-butyldiphenylsilyloxy)methyl-1-formylcyclopropane