7'-O-(4,4'-dimethoxytrityl)-5-methylmorpholino uridine

Base Information

• Chemical Name: 7'-O-(4,4'-dimethoxytrityl)-5-methylmorpholino uridine
• CAS No.: 143485-05-6
• Molecular Formula: C₃₁H₃₃N₃O₆
• Molecular Weight: 543.62
• Mol file: 143485-05-6.mol

Synonyms:7'-O-(4,4'-dimethoxytrityl)-5-methylmorpholino uridine

Chemical Property of 7'-O-(4,4'-dimethoxytrityl)-5-methylmorpholino uridine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7'-O-(4,4'-dimethoxytrityl)-5-methylmorpholino uridine

There total 6 articles about 7'-O-(4,4'-dimethoxytrityl)-5-methylmorpholino uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (138239-62-0) → 7'-O-(4,4'-dimethoxytrityl)-5-methylmorpholino uridine (143485-05-6)

Guidance literature:

1-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; With sodium periodate; ammonium biborate; In methanol; at 20 ℃; for 3h; Inert atmosphere;

With sodium cyanoborohydride; In methanol; for 6h; Inert atmosphere;

DOI:10.1039/c6ob00007j

Reference yield:

C31H33N3O8 → 7'-O-(4,4'-dimethoxytrityl)-5-methylmorpholino uridine (143485-05-6)

Guidance literature:

With sodium cyanoborohydride; In methanol; at 20 ℃; for 6h;

DOI:10.1016/j.tetlet.2008.04.035

Reference yield:

C31H30N2O8 → 7'-O-(4,4'-dimethoxytrityl)-5-methylmorpholino uridine (143485-05-6)

Guidance literature:

With ammonium biborate tetrahydrate; sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 16h;

DOI:10.1021/jacs.0c04335

upstream raw materials:

1-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate

2,4-dimethoxytrityl chloride

2',3',5'-tri-O-acetylcytidine

Downstream raw materials:

6'-O-(4,4'-dimethoxytrityl)-3'-O-cyanoethyl-1'-(N¹-thymidine) morpholino (N,N-diisopropylamino) phosphorodiamidite