4-amino-1-hydroxy-3,6-dioxo-1-phenyl-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-c]pyridine-7-carbonitrile

Base Information

• Chemical Name: 4-amino-1-hydroxy-3,6-dioxo-1-phenyl-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-c]pyridine-7-carbonitrile
• CAS No.: 1253739-07-9
• Molecular Formula: C₁₄H₁₀N₄O₃
• Molecular Weight: 282.258
• Mol file: 1253739-07-9.mol

Synonyms:4-amino-1-hydroxy-3,6-dioxo-1-phenyl-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-c]pyridine-7-carbonitrile

Chemical Property of 4-amino-1-hydroxy-3,6-dioxo-1-phenyl-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-c]pyridine-7-carbonitrile

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-amino-1-hydroxy-3,6-dioxo-1-phenyl-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-c]pyridine-7-carbonitrile

There total 5 articles about 4-amino-1-hydroxy-3,6-dioxo-1-phenyl-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-c]pyridine-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

sodium 2-benzoyl-1,1,3,3-tetracyanoprop-2-en-1-ide (1399841-93-0) → 4-amino-1-hydroxy-3,6-dioxo-1-phenyl-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-c]pyridine-7-carbonitrile (1253739-07-9)

Guidance literature:

sodium 2-benzoyl-1,1,3,3-tetracyanoprop-2-en-1-ide; With sodium hydroxide; In water; for 24h;

With sulfuric acid; In water;

DOI:10.1134/S1070428012110073

Reference yield: 67.0%

3-benzoylcyclopropane-1,1,2,2,-tetracarbonitrile (336190-07-9) → 4-amino-1-hydroxy-3,6-dioxo-1-phenyl-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-c]pyridine-7-carbonitrile (1253739-07-9)

Guidance literature:

With potassium hydroxide; In water; for 24h;

DOI:10.1134/S1070428010080282

Reference yield: 45.0%

2-amino-4-benzoyl-6-chloropyridine-3,5-dicarbonitrile (1350555-61-1) → 4-amino-1-hydroxy-3,6-dioxo-1-phenyl-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-c]pyridine-7-carbonitrile (1253739-07-9) + 4-amino-6-chloro-1-hydroxy-3-oxo-1-phenyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-7-carbonitrile

Guidance literature:

With water; sodium hydroxide; In isopropyl alcohol; at 20 ℃;

DOI:10.1007/s10593-017-2093-x

upstream raw materials:

3-benzoylcyclopropane-1,1,2,2,-tetracarbonitrile

sodium 2-benzoyl-1,1,3,3-tetracyanoprop-2-en-1-ide

potassium 2-benzoyl-1,1,3,3-tetracyanoprop-2-en-1-ide

2-amino-4-benzoyl-6-chloropyridine-3,5-dicarbonitrile