ethyl trans-1-methyl-4-(piperidin-4-yloxy)cyclohexanecarboxylate

Base Information

Chemical Name:ethyl trans-1-methyl-4-(piperidin-4-yloxy)cyclohexanecarboxylate
CAS No.:1415573-58-8
Molecular Formula:C₁₅H₂₇NO₃
Molecular Weight:269.384
Hs Code.:

Synonyms:ethyl trans-1-methyl-4-(piperidin-4-yloxy)cyclohexanecarboxylate

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Chemical Property of ethyl trans-1-methyl-4-(piperidin-4-yloxy)cyclohexanecarboxylate

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Technology Process of ethyl trans-1-methyl-4-(piperidin-4-yloxy)cyclohexanecarboxylate

There total 6 articles about ethyl trans-1-methyl-4-(piperidin-4-yloxy)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1415573-55-5
ethyl trans-1-methyl-4-(pyridin-4-yloxy)cyclohexanecarboxylate

: 1415573-58-8
ethyl trans-1-methyl-4-(piperidin-4-yloxy)cyclohexanecarboxylate

Guidance literature:: With hydrogen; acetic acid; Rh/Al₂₀₃; at 80 ℃; under 60006 Torr;

Reference yield:

: 1489-97-0
ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate

: 1415573-58-8
ethyl trans-1-methyl-4-(piperidin-4-yloxy)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 2 h / -78 °C

2.1: hydrogenchloride / water; acetone / 48 h / 20 °C

3.1: sodium tetrahydroborate; methanol / 1.5 h / 0 °C

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 48 h / 55 °C / Inert atmosphere

5.1: ChiraPak AY-H / Resolution of racemate

6.1: hydrogen; acetic acid / Rh/Al₂₀₃ / 80 °C / 60006 Torr

With hydrogenchloride; methanol; sodium tetrahydroborate; di-isopropyl azodicarboxylate; hydrogen; acetic acid; triphenylphosphine; lithium diisopropyl amide; Rh/Al₂₀₃; In tetrahydrofuran; water; acetone;

Reference yield:

: 147905-77-9
ethyl 1-methyl-4-oxo-1-cyclohexanecarboxylate

: 1415573-58-8
ethyl trans-1-methyl-4-(piperidin-4-yloxy)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate; methanol / 1.5 h / 0 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 48 h / 55 °C / Inert atmosphere

3: ChiraPak AY-H / Resolution of racemate

4: hydrogen; acetic acid / Rh/Al₂₀₃ / 80 °C / 60006 Torr

With methanol; sodium tetrahydroborate; di-isopropyl azodicarboxylate; hydrogen; acetic acid; triphenylphosphine; Rh/Al₂₀₃; In tetrahydrofuran;