tert-butyl (3-(4-((4-((2-acrylamidophenyl)amino)-5-chloropyrimidin-2-yl)amino)-2-carbamoyl-5-methylphenoxy)propyl)carbamate

Base Information

• Chemical Name: tert-butyl (3-(4-((4-((2-acrylamidophenyl)amino)-5-chloropyrimidin-2-yl)amino)-2-carbamoyl-5-methylphenoxy)propyl)carbamate
• CAS No.: 1622003-41-1
• Molecular Formula: C₂₉H₃₄ClN₇O₅
• Molecular Weight: 596.086
• Mol file: 1622003-41-1.mol

Synonyms:tert-butyl (3-(4-((4-((2-acrylamidophenyl)amino)-5-chloropyrimidin-2-yl)amino)-2-carbamoyl-5-methylphenoxy)propyl)carbamate

Chemical Property of tert-butyl (3-(4-((4-((2-acrylamidophenyl)amino)-5-chloropyrimidin-2-yl)amino)-2-carbamoyl-5-methylphenoxy)propyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (3-(4-((4-((2-acrylamidophenyl)amino)-5-chloropyrimidin-2-yl)amino)-2-carbamoyl-5-methylphenoxy)propyl)carbamate

There total 5 articles about tert-butyl (3-(4-((4-((2-acrylamidophenyl)amino)-5-chloropyrimidin-2-yl)amino)-2-carbamoyl-5-methylphenoxy)propyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

N-(2-(2,5-dichloropyrimidin-4-ylamino)phenyl)acrylamide (1622003-29-5) + tert-butyl (3-(4-amino-2-carbamoyl-5-methylphenoxy)propyl)carbamate (1622003-40-0) → tert-butyl (3-(4-((4-((2-acrylamidophenyl)amino)-5-chloropyrimidin-2-yl)amino)-2-carbamoyl-5-methylphenoxy)propyl)carbamate (1622003-41-1)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-Amyl alcohol; sodium carbonate; DavePhos; In water; at 100 ℃; for 2h; Inert atmosphere;

Reference yield:

N-tert-butoxycarbonyl-3-aminopropanol (58885-58-8) → tert-butyl (3-(4-((4-((2-acrylamidophenyl)amino)-5-chloropyrimidin-2-yl)amino)-2-carbamoyl-5-methylphenoxy)propyl)carbamate (1622003-41-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 0.58 h

2: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C

3: sodium carbonate; tert-Amyl alcohol; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos / water / 2 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-Amyl alcohol; palladium 10% on activated carbon; hydrogen; sodium hydride; sodium carbonate; DavePhos; In tetrahydrofuran; methanol; water; mineral oil;

Reference yield:

N-(2-aminophenyl)acrylamide trifluoroacetate → tert-butyl (3-(4-((4-((2-acrylamidophenyl)amino)-5-chloropyrimidin-2-yl)amino)-2-carbamoyl-5-methylphenoxy)propyl)carbamate (1622003-41-1)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 16 h / 20 °C

2: sodium carbonate; tert-Amyl alcohol; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos / water / 2 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-Amyl alcohol; sodium carbonate; N-ethyl-N,N-diisopropylamine; DavePhos; In 1-methyl-pyrrolidin-2-one; water;

upstream raw materials:

N-(2-(2,5-dichloropyrimidin-4-ylamino)phenyl)acrylamide

tert-butyl (3-(4-amino-2-carbamoyl-5-methylphenoxy)propyl)carbamate

N-tert-butoxycarbonyl-3-aminopropanol

2-fluoro-4-methyl-5-nitrobenzamide

Downstream raw materials:

C₂₄H₂₆ClN₇O₃

N¹-(3-(4-((4-((2-acrylamidophenyl)amino)-5-chloropyrimidin-2-yl)amino)-2-carbamoyl-5-methylphenoxy)propyl)-N⁵-(15-oxo-19-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10-trioxa-14-azanonadecyl)glutaramide