N^α-tert-butoxycarbonyl-N^ω-triphenylmethyl-L-asparagine hydrazide

Base Information

Chemical Name:N^α-tert-butoxycarbonyl-N^ω-triphenylmethyl-L-asparagine hydrazide
CAS No.:161001-62-3
Molecular Formula:C₂₈H₃₂N₄O₄
Molecular Weight:488.586
Hs Code.:

N<sup>α</sup>-tert-butoxycarbonyl-N<sup>ω</sup>-triphenylmethyl-L-asparagine hydrazide

Synonyms:N^α-tert-butoxycarbonyl-N^ω-triphenylmethyl-L-asparagine hydrazide

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Chemical Property of N^α-tert-butoxycarbonyl-N^ω-triphenylmethyl-L-asparagine hydrazide

Chemical Property:

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Technology Process of N^α-tert-butoxycarbonyl-N^ω-triphenylmethyl-L-asparagine hydrazide

There total 2 articles about N^α-tert-butoxycarbonyl-N^ω-triphenylmethyl-L-asparagine hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 161001-61-2
N^α-tert-butoxycarbonyl-N^ω-triphenylmethyl-L-asparagine methyl ester

: 161001-62-3
N^α-tert-butoxycarbonyl-N^ω-triphenylmethyl-L-asparagine hydrazide

Guidance literature:: With hydrazine hydrate; In methanol; at 50 ℃; for 19h;

Reference yield:

: 132388-68-2
N^α-tert-butoxycarbonyl-N^ω-triphenylmethyl-L-asparagine

: 161001-62-3
N^α-tert-butoxycarbonyl-N^ω-triphenylmethyl-L-asparagine hydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether

2: 65 percent / hydrazine hydrate / methanol / 19 h / 50 °C

With hydrazine hydrate; In methanol; diethyl ether;

Reference yield:

: 161001-62-3
N^α-tert-butoxycarbonyl-N^ω-triphenylmethyl-L-asparagine hydrazide

: α-benzyloxycarbonyl-N^ω-triphenylmethyl-L-asparaginyl)hydrazino>sulfonyl-L-prolyl-L-isoleucyl-L-valine methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: methanol / 12 h / 50 °C

2: toluene-p-sulfonic acid, NaBH₃CN, Bromocresol Green indicator / tetrahydrofuran / 15 h

3: 55 percent / Et₃N / CH₂Cl₂ / 66 h / Heating

4: H₂ / Pd-C / dimethylformamide; ethanol / 1 h

5: 58 percent / dicyclohexylcarbodiimide, Et₃N, 1-hydroxybenzotriazole / dimethylformamide / Ambient temperature

6: HCl / methanol / 1 h / Ambient temperature

7: 85 percent / Et₃N / tetrahydrofuran; H₂O / Ambient temperature

With hydrogenchloride; hydrogen; bromocresol green; sodium cyanoborohydride; benzotriazol-1-ol; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;