1-[(2R,3R,4S,5S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-5-phenyl-pyrrolidin-1-yl]-2,2,2-trifluoro-ethanone

Base Information

Chemical Name:1-[(2R,3R,4S,5S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-5-phenyl-pyrrolidin-1-yl]-2,2,2-trifluoro-ethanone
CAS No.:175480-87-2
Molecular Formula:C₄₀H₄₆F₃NO₆Si
Molecular Weight:721.889
Hs Code.:

1-[(2R,3R,4S,5S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-5-phenyl-pyrrolidin-1-yl]-2,2,2-trifluoro-ethanone

Synonyms:1-[(2R,3R,4S,5S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-5-phenyl-pyrrolidin-1-yl]-2,2,2-trifluoro-ethanone

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Chemical Property of 1-[(2R,3R,4S,5S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-5-phenyl-pyrrolidin-1-yl]-2,2,2-trifluoro-ethanone

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Technology Process of 1-[(2R,3R,4S,5S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-5-phenyl-pyrrolidin-1-yl]-2,2,2-trifluoro-ethanone

There total 4 articles about 1-[(2R,3R,4S,5S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-5-phenyl-pyrrolidin-1-yl]-2,2,2-trifluoro-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 175480-86-1
1-{(2R,3R,4S,5S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,4-dihydroxy-5-phenyl-pyrrolidin-1-yl}-2,2,2-trifluoro-ethanone

: 1-[(2R,3R,4S,5S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-phenyl-pyrrolidin-1-yl]-2,2,2-trifluoro-ethanone

: 175480-87-2
1-[(2R,3R,4S,5S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-5-phenyl-pyrrolidin-1-yl]-2,2,2-trifluoro-ethanone

Guidance literature:: With pyridine; silver perchlorate; In tetrahydrofuran; Title compound not separated from byproducts;
DOI:10.1021/ja9600385

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 175480-87-2
1-[(2R,3R,4S,5S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-5-phenyl-pyrrolidin-1-yl]-2,2,2-trifluoro-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / Et₃N, DMAP, pyridine

2: 31 percent / AgClO₄, pyridine / tetrahydrofuran

With pyridine; dmap; silver perchlorate; triethylamine; In tetrahydrofuran;
DOI:10.1021/ja9600385

Reference yield:

: 151265-55-3
1,4-dideoxy-1,4-imino-1-(S)-phenyl-D-ribitol

: 175480-87-2
1-[(2R,3R,4S,5S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-5-phenyl-pyrrolidin-1-yl]-2,2,2-trifluoro-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) pyridine, 2.) conc. NH₄OH / 2.) MeOH

2: 81 percent / Et₃N, DMAP, pyridine

3: 31 percent / AgClO₄, pyridine / tetrahydrofuran

With pyridine; dmap; ammonium hydroxide; silver perchlorate; triethylamine; In tetrahydrofuran;
DOI:10.1021/ja9600385