(2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-9-(tetrahydro-2H-pyran-2-yloxy)nonanamide

Base Information

Chemical Name:(2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-9-(tetrahydro-2H-pyran-2-yloxy)nonanamide
CAS No.:1019973-17-1
Molecular Formula:C₂₃H₃₁F₃N₂O₄
Molecular Weight:456.505
Hs Code.:

Synonyms:(2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-9-(tetrahydro-2H-pyran-2-yloxy)nonanamide

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Chemical Property of (2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-9-(tetrahydro-2H-pyran-2-yloxy)nonanamide

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Technology Process of (2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-9-(tetrahydro-2H-pyran-2-yloxy)nonanamide

There total 1 articles about (2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-9-(tetrahydro-2H-pyran-2-yloxy)nonanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 53963-10-3
2-[(6-bromohexyl)oxy]tetrahydro-2H-pyran

: 512776-95-3
(2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide

: 1019973-17-1
(2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-9-(tetrahydro-2H-pyran-2-yloxy)nonanamide

Guidance literature:: 2-[(6-bromohexyl)oxy]tetrahydro-2H-pyran; With magnesium; In tetrahydrofuran; at 20 - 50 ℃; for 0.5h; Heating / reflux;

With thien-2-yl(cyano)copper lithium; In tetrahydrofuran; at -78 ℃;

(2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide; With ammonia; ammonium chloride; more than 3 stages;