3-((3,5-bis(trifluoromethyl)phenyl)amino)-N,N-diethyl-2,3-dihydrobenzofuran-2-carboxamide

Base Information

Chemical Name:3-((3,5-bis(trifluoromethyl)phenyl)amino)-N,N-diethyl-2,3-dihydrobenzofuran-2-carboxamide
CAS No.:1431151-88-0
Molecular Formula:C₂₁H₂₀F₆N₂O₂
Molecular Weight:446.392
Hs Code.:

Synonyms:3-((3,5-bis(trifluoromethyl)phenyl)amino)-N,N-diethyl-2,3-dihydrobenzofuran-2-carboxamide

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Chemical Property of 3-((3,5-bis(trifluoromethyl)phenyl)amino)-N,N-diethyl-2,3-dihydrobenzofuran-2-carboxamide

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Technology Process of 3-((3,5-bis(trifluoromethyl)phenyl)amino)-N,N-diethyl-2,3-dihydrobenzofuran-2-carboxamide

There total 5 articles about 3-((3,5-bis(trifluoromethyl)phenyl)amino)-N,N-diethyl-2,3-dihydrobenzofuran-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 503593-98-4
(E)-2-(((3,5-bis(trifluoromethyl)phenyl)imino)methyl)phenol

: (diethylcarbamoyl)methyl-[(1R, 2S, 3R)-2-methoxy-1,7,7-trimethylbicyclo[2.2.1] hept-3-yl]methylsulfonium bromide

: 1431151-88-0
3-((3,5-bis(trifluoromethyl)phenyl)amino)-N,N-diethyl-2,3-dihydrobenzofuran-2-carboxamide

Guidance literature:: (E)-2-(((3,5-bis(trifluoromethyl)phenyl)imino)methyl)phenol; (diethylcarbamoyl)methyl-[(1R, 2S, 3R)-2-methoxy-1,7,7-trimethylbicyclo[2.2.1] hept-3-yl]methylsulfonium bromide; In toluene; at 0 ℃; Molecular sieve;

With N,N,N',N'-tetramethylguanidine; In toluene; at 0 ℃; for 24h; Reagent/catalyst; Solvent; Time; enantioselective reaction; Molecular sieve;
DOI:10.1016/j.tet.2013.03.059

Reference yield:

: 503593-98-4
(E)-2-(((3,5-bis(trifluoromethyl)phenyl)imino)methyl)phenol

: (diethylcarbamoyl)methyl-[(1R, 2S, 3R)-2-methoxy-1,7,7-trimethylbicyclo[2.2.1] hept-3-yl]methylsulfonium bromide

: 1431151-88-0
3-((3,5-bis(trifluoromethyl)phenyl)amino)-N,N-diethyl-2,3-dihydrobenzofuran-2-carboxamide

: 3-((3,5-bis(trifluoromethyl)phenyl)amino)-N,N-diethyl-2,3-dihydrobenzofuran-2-carboxamide

Guidance literature:: (E)-2-(((3,5-bis(trifluoromethyl)phenyl)imino)methyl)phenol; (diethylcarbamoyl)methyl-[(1R, 2S, 3R)-2-methoxy-1,7,7-trimethylbicyclo[2.2.1] hept-3-yl]methylsulfonium bromide; In tetrahydrofuran; at 20 ℃; Molecular sieve;

With cesium hydroxide; In tetrahydrofuran; at 20 ℃; for 14h; Reagent/catalyst; Solvent; Time; Overall yield = 60 %; enantioselective reaction; Molecular sieve;
DOI:10.1016/j.tet.2013.03.059

Reference yield:

: 328-74-5
3,5-Bis-(trifluoromethyl)aniline

: 1431151-88-0
3-((3,5-bis(trifluoromethyl)phenyl)amino)-N,N-diethyl-2,3-dihydrobenzofuran-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 2 h / 20 °C

2.1: toluene / 30?min / 0 °C / Molecular sieve

2.2: 24 h / 0 °C / Molecular sieve

In ethanol; toluene;
DOI:10.1016/j.tet.2013.03.059