1,3-Bis(benzenesulfonyloxy)-5-benzyloxybenzene

Base Information

• Chemical Name: 1,3-Bis(benzenesulfonyloxy)-5-benzyloxybenzene
• CAS No.: 120349-81-7
• Molecular Formula: C₂₅H₂₀O₇S₂
• Molecular Weight: 496.562
• Mol file: 120349-81-7.mol

Synonyms:1,3-Bis(benzenesulfonyloxy)-5-benzyloxybenzene

Chemical Property of 1,3-Bis(benzenesulfonyloxy)-5-benzyloxybenzene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1,3-Bis(benzenesulfonyloxy)-5-benzyloxybenzene

There total 1 articles about 1,3-Bis(benzenesulfonyloxy)-5-benzyloxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

Phloroglucinol dibenzenesulfonate (3991-76-2) + benzyl bromide (100-39-0) → 1,3-Bis(benzenesulfonyloxy)-5-benzyloxybenzene (120349-81-7)

Guidance literature:

With potassium carbonate; In acetone; for 3.5h; Heating;

DOI:10.1055/s-1988-27700

Reference yield: 62.0%

1,3-Bis(benzenesulfonyloxy)-5-benzyloxybenzene (120349-81-7) → 1-Benzenesulfonyloxy-3-benzyloxy-5-hydroxybenzene (120349-82-8)

Guidance literature:

With potassium hydroxide; In methanol; for 4h; Ambient temperature;

DOI:10.1055/s-1988-27700

Reference yield:

1,3-Bis(benzenesulfonyloxy)-5-benzyloxybenzene (120349-81-7) → Benzenesulfonic acid 4-benzyloxy-2-oxo-2,3,3a,8a-tetrahydro-benzo[b]furo[3,2-d]furan-6-yl ester (120349-88-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 62 percent / KOH / methanol / 4 h / Ambient temperature

2: 48 percent / HCl, KI, KIO₃ / methanol; H₂O / 1 h

3: 1.) K₂CO₃ / 1.) tetra-n-butylammonium bromide / 1.) CH₂Cl₂, water, room temp., 10 min, 2.) CH₂Cl₂, water, room temp., 1 h

4: 51 percent / Et₃N, formic acid / Pd(CH₃CN)2Cl₂ / dimethylformamide / 1 h / 35 °C

With hydrogenchloride; potassium iodate; potassium hydroxide; formic acid; potassium carbonate; triethylamine; potassium iodide; dichloro bis(acetonitrile) palladium(II); tetrabutylammomium bromide; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1055/s-1988-27700

upstream raw materials:

Phloroglucinol dibenzenesulfonate

benzyl bromide

Downstream raw materials:

1-Benzenesulfonyloxy-3-benzyloxy-5-hydroxybenzene

1-benzenesulfonyloxy-3-benzyloxy-5-hydroxy-4-iodobenzene

Benzenesulfonic acid 4-benzyloxy-2-oxo-2,3,3a,8a-tetrahydro-benzo[b]furo[3,2-d]furan-6-yl ester

Benzenesulfonic acid 3-benzyloxy-4-iodo-5-(5-oxo-2,5-dihydro-furan-2-yloxy)-phenyl ester

Refernces