benzyl-1, hydroxy-1-dihydro-1,2-benzocyclobutene

Base Information

• Chemical Name: benzyl-1, hydroxy-1-dihydro-1,2-benzocyclobutene
• CAS No.: 77287-66-2
• Molecular Formula: C₁₅H₁₄O
• Molecular Weight: 210.276
• Mol file: 77287-66-2.mol

Synonyms:benzyl-1, hydroxy-1-dihydro-1,2-benzocyclobutene

Chemical Property of benzyl-1, hydroxy-1-dihydro-1,2-benzocyclobutene

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of benzyl-1, hydroxy-1-dihydro-1,2-benzocyclobutene

There total 6 articles about benzyl-1, hydroxy-1-dihydro-1,2-benzocyclobutene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

benzocyclobutenone (3469-06-5) → benzyl-1, hydroxy-1-dihydro-1,2-benzocyclobutene (77287-66-2)

Guidance literature:

DOI:10.1016/S0040-4039(01)81858-X

Reference yield: 40.0%

2-Bromo-trans-β-benzylstyrene Oxide (77287-64-0) → benzyl-1, hydroxy-1-dihydro-1,2-benzocyclobutene (77287-66-2) + 1,3-Diphenylpropanone (102-04-5)

Guidance literature:

With n-butyllithium; magnesium bromide; Yield given. Multistep reaction; 1.) THF, hexane, -78 deg C, 5 min, 2.) ether and warmed to room temperature;

DOI:10.1021/jo00326a026

Reference yield:

benzocyclobutenone (3469-06-5) + benzyl chloride (100-44-7) → benzyl-1, hydroxy-1-dihydro-1,2-benzocyclobutene (77287-66-2)

Guidance literature:

With magnesium; Yield given. Multistep reaction; 1.) ether; 2.) ether;

DOI:10.1016/S0040-4020(01)96432-4

upstream raw materials:

2-Bromo-trans-β-benzylstyrene Oxide

benzocyclobutenone

benzyl chloride

phenylacetaldehyde

Downstream raw materials:

benzyl-1, azido-1-dihydro-1,2-benzocyclobutene

2-benzylindole