Acetylthioessigsaeure-S-benzylester

Base Information

• Chemical Name: Acetylthioessigsaeure-S-benzylester
• CAS No.: 54565-04-7
• Molecular Formula: C₁₁H₁₂O₂S
• Molecular Weight: 208.281
• Mol file: 54565-04-7.mol

Synonyms:Acetylthioessigsaeure-S-benzylester

Chemical Property of Acetylthioessigsaeure-S-benzylester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of Acetylthioessigsaeure-S-benzylester

There total 5 articles about Acetylthioessigsaeure-S-benzylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,2,6-trimethyl-4H-1,3-dioxin-4-one (5394-63-8) + phenylmethanethiol (100-53-8) → Acetylthioessigsaeure-S-benzylester (54565-04-7)

Guidance literature:

In toluene; Heating;

DOI:10.1248/cpb.38.2262

Reference yield: 71.0%

acetoacetic acid methyl ester (105-45-3) + phenylmethanethiol (100-53-8) → Acetylthioessigsaeure-S-benzylester (54565-04-7)

Guidance literature:

With natural kaolinitic clay; In toluene; for 6h; Heating; further reagent: Montmorillonite K₁₀ clay;

DOI:10.1021/jo971404l

Reference yield: 10.0%

S-benzyl malonic acid half thioester (61668-14-2) → benzylthioacetate (32362-99-5) + Acetylthioessigsaeure-S-benzylester (54565-04-7) + 4-benzylsulfanylcarbonyl-3-oxo-butyric acid

Guidance literature:

With 1H-imidazole; magnesium acetate; In tetrahydrofuran; at 20 ℃; for 96h;

DOI:10.3390/61100845

upstream raw materials:

2,2,6-trimethyl-4H-1,3-dioxin-4-one

phenylmethanethiol

acetoacetic acid methyl ester

S-benzyl malonic acid half thioester

Downstream raw materials:

(E)-3-Amino-but-2-enethioic acid S-benzyl ester

2',6'-Dimethyl-[3,4']bipyridinyl-3',5'-dicarbothioic acid di-S-benzyl ester

1-Ethyl-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarbothioic acid di-S-benzyl ester

1,2,6-Trimethyl-1,4-dihydro-pyridine-3,5-dicarbothioic acid di-S-benzyl ester

Refernces

• 1、 Roh, Eun Joo,Keller, Jason M.,Olah, Zoltan,Iadarola, Michael J.,Jacobson, Kenneth A.. "Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1)". experimental part. p. 9349 - 9358. Retrieved 2009/04/06.
• 2、 Sakaki,Kobayashi,Sato,Kaneko. "A novel synthesis of β-ketothioesters". . p. 2262 - 2264. Retrieved 2007/10/02.