[1-(4-bromobenzenesulfonyl)-6-methoxy-1H-indol-3-yl]-(3,4,5-trimethoxyphenyl)methanone

Base Information

Chemical Name:[1-(4-bromobenzenesulfonyl)-6-methoxy-1H-indol-3-yl]-(3,4,5-trimethoxyphenyl)methanone
CAS No.:1221257-69-7
Molecular Formula:C₂₅H₂₂BrNO₇S
Molecular Weight:560.422
Hs Code.:

Synonyms:[1-(4-bromobenzenesulfonyl)-6-methoxy-1H-indol-3-yl]-(3,4,5-trimethoxyphenyl)methanone

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Chemical Property of [1-(4-bromobenzenesulfonyl)-6-methoxy-1H-indol-3-yl]-(3,4,5-trimethoxyphenyl)methanone

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Technology Process of [1-(4-bromobenzenesulfonyl)-6-methoxy-1H-indol-3-yl]-(3,4,5-trimethoxyphenyl)methanone

There total 1 articles about [1-(4-bromobenzenesulfonyl)-6-methoxy-1H-indol-3-yl]-(3,4,5-trimethoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 98-58-8
4-bromobenzenesulfonyl chloride

: 613679-11-1
(6-methoxy-1H-indol-3-yl)(3,4,5-trimethoxyphenyl)methanone

: 1221257-69-7
[1-(4-bromobenzenesulfonyl)-6-methoxy-1H-indol-3-yl]-(3,4,5-trimethoxyphenyl)methanone

Guidance literature:: With triethylamine; In dichloromethane; for 3h;

Reference yield:

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 1221257-69-7
[1-(4-bromobenzenesulfonyl)-6-methoxy-1H-indol-3-yl]-(3,4,5-trimethoxyphenyl)methanone

: C₃₂H₃₃NO₉S

Guidance literature:: With palladium diacetate; potassium carbonate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; at 100 ℃; for 5h; Inert atmosphere;
DOI:10.1016/j.ejmech.2016.11.033

Reference yield:

: 1221257-69-7
[1-(4-bromobenzenesulfonyl)-6-methoxy-1H-indol-3-yl]-(3,4,5-trimethoxyphenyl)methanone

: C₃₃H₃₄N₂O₁₀S

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; palladium diacetate; potassium carbonate; triethylamine / N,N-dimethyl-formamide / 5 h / 100 °C / Inert atmosphere

2: trifluoroacetic acid / 16 h / 20 °C / Inert atmosphere

3: benzotriazol-1-ol; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; palladium diacetate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic acid; In N,N-dimethyl-formamide; 1: |Heck Reaction;
DOI:10.1016/j.ejmech.2016.11.033