613679-11-1

Upstream product

• 3189-13-7 6-methoxylindole 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 
• 1885-35-4 3,4,5-trimethoxybenzonitrile 
• 22996-21-0 4-methoxy-2-nitro-benzaldehyde 
• 59236-36-1 2-amino-4-methoxybenzaldehyde 
• 10078-55-4 1-(3,4,5-trimethoxyphenyl)prop-2-yn-1-one 
• 24171-80-0 N-(3-methoxyphenyl)hydroxylamine 
• 555-03-3 3-nitroanisole 
• 1221257-68-6 1-(2-(tert-butyldimethylsilyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)-1H-indol-1-yl)ethanone 
• 753488-72-1 (6-methoxy-indol-1-yl)-(3,4,5-trimethoxy-phenyl)-methanone 
• 99546-93-7 N-(2,2-diethoxyethyl)-N-(3-methoxyphenyl)-benzene-sulfonamide 
• 22865-27-6 N-(3-methoxyphenyl)benzenesulfonamide 
• 56995-13-2 6-methoxy-1-(phenylsulfonyl)-1H-indole 
• 896462-36-5 (1-benzenesulfonyl-6-methoxy-1H-indol-3-yl)-(3,4,5-trimethoxy-phenyl)-methanone 

Downstream Products

• 613679-13-3 (6-methoxy-1-pyridin-4-ylmethyl-1H-indol-3-yl)-(3,4,5-trimethoxy-phenyl)-methanone 
• 1221257-69-7 [1-(4-bromobenzenesulfonyl)-6-methoxy-1H-indol-3-yl]-(3,4,5-trimethoxyphenyl)methanone 
• 1221258-40-7 tert-butyl 5-((6-methoxy-3-(3,4,5-trimethoxybenzoyl)-1H-indol-1-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate 
• 1221257-74-4 (1-(3-(4-iodophenyl)prop-2-ynyl)-6-methoxy-1H-indol-3-yl)(3,4,5-trimethoxyphenyl)methanone 

Relevant academic research and scientific papers

A general and scalable synthesis of polysubstituted indoles

A consecutive 2-step synthesis of N-unprotected polysubstituted indoles bearing an electron-withdrawing group at the C-3 position from readily available nitroarenes is reported. The protocol is based on the [3,3]-sigmatropic rearrangement of N-oxyenamines generated by the DABCO-catalyzed reaction of N-arylhydroxylamines and conjugated terminal alkynes, and delivers indoles endowed with a wide array of substitution patterns and topologies.

Decarboxylative acylation of: N -free indoles enabled by a catalytic amount of copper catalyst and liquid-assisted grinding

A facile decarboxylative acylation of N-free indoles with α-ketonates via liquid-assisted grinding was reported. The reaction requires only a catalytic amount of Cu(OAc)2·H2O in combination with O2 as the terminal oxidant to give various 3-acylindoles with high efficiency. Additionally, this new methodology was applicable to a gram-scale synthesis.

Synthesis of 3-acylindoles by oxidative rearrangement of 2-aminochalcones using a hypervalent iodine reagent and cyclization sequence

An efficient one-pot method was developed for the construction of 3-acylindoles via oxidative rearrangement of 2-aminochalcones followed by intramolecular cyclization. The reaction was used to convert a variety of 2-aminochalcones into 3-acylindoles in mo

Palladium catalyzed addition of arylboronic acid or indole to nitriles: Synthesis of aryl ketones

Aryl ketones can be synthesized conveniently by a palladium catalyzed addition of arylboronic acid to nitriles in aqueous triflic acid. This catalytic system was extended to the addition of unprotected indoles to nitriles under a slightly modified condition to produce 3-acyl indoles in good yields.

S1P RECEPTORS MODULATORS

The invention relates to novel compounds that have S1P receptor modulating activity and, preferably, apoptotic activity and/or anti proliferative activity against cancer cells and other cell types. Further, the invention relates to a pharmaceutical comprising at least one compound of the invention for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression, for example, cancer. A further aspect of the invention relates to the use of a pharmaceutical comprising at least one compound of the invention for the manufacture of a medicament for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression such as cancer.

Synthesis and biological evaluation of (3,4,5-trimethoxyphenyl)indol-3-ylmethane derivatives as potential antivascular agents

Combretastatin A-4 (CSA-4), a stilbene derivative, is a potent vascular disrupting agent (VDA) with the structural requirement of a cis-configuration to maintain a molecular geometry and a correct orientation of both phenyl groups. A series of indolic ana

Indole compounds as inhibitors of tubulin polymerisation for the treatment of angiogenesis-related disorders

Indole compounds of the formula: wherein L1 is CO; L2 is a bond; R1 is aryl or heteroaryl; R2 is H, aryl, heteroaryl, halogen, nitro, nitroso, cyano, azide, isothionitro, OR, OC(O)R, OC(O)OR, OC(O)NRR', SO2

Indole compounds

This invention relates to methods of inhibiting tubulin polymerization and treating cancer and other angiogenesis-related disorders with indole compounds of the formula: wherein L1, L2, R1, R2, Ra, R

Indole compounds

Indole compounds of the formula: wherein L1, L2, R1, R2, Ra, Rb, Rc, Rd, and Re are defined herein. Also disclosed are methods of using of the indole compou

Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents

The synthesis and study of the structure-activity relationships of two new classes of synthetic antitubulin compounds based on 1-aroylindole and 3-aroylindole skeletons are described. Lead compounds 3, 10, and 14 displayed potent cytotoxicities with ICsu