3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)2-(2-chlorobenzyl)-N-methyl-N-cyclopropylpropanamide

Base Information

Chemical Name:3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)2-(2-chlorobenzyl)-N-methyl-N-cyclopropylpropanamide
CAS No.:1378389-87-7
Molecular Formula:C₂₅H₃₀ClFN₂O₂S
Molecular Weight:477.043
Hs Code.:

Synonyms:3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)2-(2-chlorobenzyl)-N-methyl-N-cyclopropylpropanamide

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Chemical Property of 3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)2-(2-chlorobenzyl)-N-methyl-N-cyclopropylpropanamide

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Technology Process of 3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)2-(2-chlorobenzyl)-N-methyl-N-cyclopropylpropanamide

There total 2 articles about 3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)2-(2-chlorobenzyl)-N-methyl-N-cyclopropylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: C₂HF₃O₂*C₂₁H₂₃ClFNO₃S

: 67376-94-7
methylcyclopropylamine hydrochloride

: 1378389-87-7
3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)2-(2-chlorobenzyl)-N-methyl-N-cyclopropylpropanamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/jm201629q

Reference yield:

: 1283095-53-3
tert-butyl 2-[(2-chlorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)propanoate

: 1378389-87-7
3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)2-(2-chlorobenzyl)-N-methyl-N-cyclopropylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 18 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jm201629q

Reference yield:

: 1378389-87-7
3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)2-(2-chlorobenzyl)-N-methyl-N-cyclopropylpropanamide

: 3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)2-(2-chlorobenzyl)-N-methyl-N-cyclopropylpropanamide

: 3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)2-(2-chlorobenzyl)-N-methyl-N-cyclopropylpropanamide

Guidance literature:: With CAPCELL PAK C₁₈ MG column; In water; acetonitrile; trifluoroacetic acid; at 45 ℃; Resolution of racemate;
DOI:10.1021/jm201629q