tert-butyl 2-[(2-chlorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)propanoate

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Chemical Name:tert-butyl 2-[(2-chlorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)propanoate
CAS No.:1283095-53-3
Molecular Formula:C₂₅H₃₁ClFNO₃S
Molecular Weight:480.043
Hs Code.:

Synonyms:tert-butyl 2-[(2-chlorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)propanoate

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Chemical Property of tert-butyl 2-[(2-chlorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)propanoate

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Technology Process of tert-butyl 2-[(2-chlorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)propanoate

There total 7 articles about tert-butyl 2-[(2-chlorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1283095-51-1
t-butyl 3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)propanoate

: 611-17-6
1-bromomethyl-2-chlorobenzene

: 1283095-53-3
tert-butyl 2-[(2-chlorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)propanoate

Guidance literature:: t-butyl 3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)propanoate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1.5h;

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; at -78 ℃; for 0.5h;

1-bromomethyl-2-chlorobenzene; In tetrahydrofuran; at -78 - 0 ℃; for 1h;
DOI:10.1021/jm101487v

Reference yield:

: 13781-67-4
3-(2-hydroxyethyl)thiophene

: 1283095-53-3
tert-butyl 2-[(2-chlorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: trifluoroacetic acid / dichloromethane / 20.5 h / 20 °C

2.1: triethylamine / dichloromethane / 5 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 3 h / 20 °C

5.1: triethylamine / tetrahydrofuran / 20 h / 65 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -78 °C

6.2: 0.5 h / -78 °C

6.3: 1 h / -78 - 0 °C

With hydrogenchloride; n-butyllithium; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane;
DOI:10.1021/jm101487v

Reference yield:

: 1283095-48-6
tert-butyl-4′,5′-dihydro-1H-spiro[piperidine-4,7′-thieno[2,3-c]pyran]-1-carboxylate

: 1283095-53-3
tert-butyl 2-[(2-chlorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 3 h / 20 °C

3.1: triethylamine / tetrahydrofuran / 20 h / 65 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -78 °C

4.2: 0.5 h / -78 °C

4.3: 1 h / -78 - 0 °C

With hydrogenchloride; n-butyllithium; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane;
DOI:10.1021/jm101487v