(E)-2-(1-Phenyl-allyl)-3-piperidin-1-yl-but-2-enedioic acid dimethyl ester

Base Information

Chemical Name:(E)-2-(1-Phenyl-allyl)-3-piperidin-1-yl-but-2-enedioic acid dimethyl ester
CAS No.:154261-07-1
Molecular Formula:C₂₀H₂₅NO₄
Molecular Weight:343.423
Hs Code.:

Synonyms:(E)-2-(1-Phenyl-allyl)-3-piperidin-1-yl-but-2-enedioic acid dimethyl ester

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Chemical Property of (E)-2-(1-Phenyl-allyl)-3-piperidin-1-yl-but-2-enedioic acid dimethyl ester

Chemical Property:

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Technology Process of (E)-2-(1-Phenyl-allyl)-3-piperidin-1-yl-but-2-enedioic acid dimethyl ester

There total 1 articles about (E)-2-(1-Phenyl-allyl)-3-piperidin-1-yl-but-2-enedioic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5882-82-6
(E)-1-(3-phenylallyl)piperidine

: 762-42-5
dimethyl acetylenedicarboxylate

: 154261-07-1
(E)-2-(1-Phenyl-allyl)-3-piperidin-1-yl-but-2-enedioic acid dimethyl ester

Guidance literature:: With toluene-4-sulfonic acid; In diethyl ether; dichloromethane; at 25 ℃; for 45h;
DOI:10.1021/ja00081a019

Reference yield:

: 154261-07-1
(E)-2-(1-Phenyl-allyl)-3-piperidin-1-yl-but-2-enedioic acid dimethyl ester

: 2-Oxo-3-(1-phenyl-allyl)-succinic acid dimethyl ester

Guidance literature:: With sulfuric acid; In diethyl ether; at 20 ℃; for 11h; Yield given;
DOI:10.1021/ja00081a019

Reference yield:

: 154261-07-1
(E)-2-(1-Phenyl-allyl)-3-piperidin-1-yl-but-2-enedioic acid dimethyl ester

: (S,R)-N-benzylmethyl-3-phenyl-4-pentenamide

Guidance literature:: Multi-step reaction with 5 steps

1: 2M aq. H₂SO₄ / diethyl ether / 11 h / 20 °C

2: 5 M aq. NaOH / diethyl ether / 24 h / 23 °C

3: 5 M aq. NaOH / diethyl ether / 40 h

4: Et₃N / CH₂Cl₂ / 0.2 h / 3 °C

5: CH₂Cl₂ / 18 h / 20 °C

With sodium hydroxide; sulfuric acid; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1021/ja00081a019