(S)-ethyl 3-(2-((tert-butoxycarbonyl)amino)acetamido)-3-(3-(tert-butyl)-5-(pyridin-3-yl)phenyl)propanoate

Base Information

Chemical Name:(S)-ethyl 3-(2-((tert-butoxycarbonyl)amino)acetamido)-3-(3-(tert-butyl)-5-(pyridin-3-yl)phenyl)propanoate
CAS No.:1541199-14-7
Molecular Formula:C₂₇H₃₇N₃O₅
Molecular Weight:483.608
Hs Code.:

Synonyms:(S)-ethyl 3-(2-((tert-butoxycarbonyl)amino)acetamido)-3-(3-(tert-butyl)-5-(pyridin-3-yl)phenyl)propanoate

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Chemical Property of (S)-ethyl 3-(2-((tert-butoxycarbonyl)amino)acetamido)-3-(3-(tert-butyl)-5-(pyridin-3-yl)phenyl)propanoate

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Technology Process of (S)-ethyl 3-(2-((tert-butoxycarbonyl)amino)acetamido)-3-(3-(tert-butyl)-5-(pyridin-3-yl)phenyl)propanoate

There total 8 articles about (S)-ethyl 3-(2-((tert-butoxycarbonyl)amino)acetamido)-3-(3-(tert-butyl)-5-(pyridin-3-yl)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1541197-73-2
(S)-3-(3-bromo-5-tert-butylphenyl)-3-(2-tert-butoxycarbonylaminoacetylamino)propionic acid ethyl ester

: 1692-25-7
3-pyridylboronic acid

: 1541199-14-7
(S)-ethyl 3-(2-((tert-butoxycarbonyl)amino)acetamido)-3-(3-(tert-butyl)-5-(pyridin-3-yl)phenyl)propanoate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In water; N,N-dimethyl-formamide; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

: 129316-09-2
1,3-dibromo-5-t-butylbenzene

: 1541199-14-7
(S)-ethyl 3-(2-((tert-butoxycarbonyl)amino)acetamido)-3-(3-(tert-butyl)-5-(pyridin-3-yl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: ammonium acetate / isopropyl alcohol / 14 h / Reflux; Inert atmosphere

3.1: hydrogenchloride / 1.5 h / Reflux

4.1: water; sodium hydroxide

4.2: 20 °C / pH 8.2 / Enzymatic reaction

5.1: hydrogenchloride / 2 h / Reflux

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / N,N-dimethyl-formamide; water / 2 h / 80 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; ammonium acetate; water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In diethyl ether; hexane; water; N,N-dimethyl-formamide; isopropyl alcohol; 7.1: |Suzuki Coupling;

Reference yield:

: 241155-85-1
3-bromo-5-formyl-tert-butylbenzene

: 1541199-14-7
(S)-ethyl 3-(2-((tert-butoxycarbonyl)amino)acetamido)-3-(3-(tert-butyl)-5-(pyridin-3-yl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium acetate / isopropyl alcohol / 14 h / Reflux; Inert atmosphere

2.1: hydrogenchloride / 1.5 h / Reflux

3.1: water; sodium hydroxide

3.2: 20 °C / pH 8.2 / Enzymatic reaction

4.1: hydrogenchloride / 2 h / Reflux

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / N,N-dimethyl-formamide; water / 2 h / 80 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In water; N,N-dimethyl-formamide; isopropyl alcohol; 6.1: |Suzuki Coupling;