(S)-3-(3-bromo-5-tert-butylphenyl)-3-(2-tert-butoxycarbonylaminoacetylamino)propionic acid ethyl ester

Base Information

• Chemical Name: (S)-3-(3-bromo-5-tert-butylphenyl)-3-(2-tert-butoxycarbonylaminoacetylamino)propionic acid ethyl ester
• CAS No.: 1541197-73-2
• Molecular Formula: C₂₂H₃₃BrN₂O₅
• Molecular Weight: 485.418
• Mol file: 1541197-73-2.mol

Synonyms:(S)-3-(3-bromo-5-tert-butylphenyl)-3-(2-tert-butoxycarbonylaminoacetylamino)propionic acid ethyl ester

Chemical Property of (S)-3-(3-bromo-5-tert-butylphenyl)-3-(2-tert-butoxycarbonylaminoacetylamino)propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-(3-bromo-5-tert-butylphenyl)-3-(2-tert-butoxycarbonylaminoacetylamino)propionic acid ethyl ester

There total 12 articles about (S)-3-(3-bromo-5-tert-butylphenyl)-3-(2-tert-butoxycarbonylaminoacetylamino)propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

BOC-glycine (4530-20-5) + (S)-ethyl 3-amino-3-(3-bromo-5-tert-butylphenyl)propionate hydrochloride → (S)-3-(3-bromo-5-tert-butylphenyl)-3-(2-tert-butoxycarbonylaminoacetylamino)propionic acid ethyl ester (1541197-73-2)

Guidance literature:

BOC-glycine; (S)-ethyl 3-amino-3-(3-bromo-5-tert-butylphenyl)propionate hydrochloride; With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In acetonitrile; for 0.25h; Inert atmosphere; Cooling with ice;

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1039/d0ob01495h

Reference yield: 46.0%

BOC-glycine (4530-20-5) + (S)-3-amino-3-(3-bromo-5-tert-butylphenyl)propionicacid ethyl ester (1541197-71-0) → (S)-3-(3-bromo-5-tert-butylphenyl)-3-(2-tert-butoxycarbonylaminoacetylamino)propionic acid ethyl ester (1541197-73-2)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h; Inert atmosphere;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (S)-3-(2-aminoacetylamino)-3-(3-bromo-5-tert-butylphenyl)propionic acid ethyl ester hydrochloride salt (1541197-63-0) → (S)-3-(3-bromo-5-tert-butylphenyl)-3-(2-tert-butoxycarbonylaminoacetylamino)propionic acid ethyl ester (1541197-73-2)

Guidance literature:

(S)-3-(2-aminoacetylamino)-3-(3-bromo-5-tert-butylphenyl)propionic acid ethyl ester hydrochloride salt; With sodium hydrogencarbonate; In 1,4-dioxane; water; at 20 ℃; for 0.0833333h;

di-tert-butyl dicarbonate; In 1,4-dioxane; water; at 0 - 20 ℃; for 2h;

upstream raw materials:

di-tert-butyl dicarbonate

(S)-3-(2-aminoacetylamino)-3-(3-bromo-5-tert-butylphenyl)propionic acid ethyl ester hydrochloride salt

1,3-dibromo-5-t-butylbenzene

3-bromo-5-formyl-tert-butylbenzene

Downstream raw materials:

(S)-ethyl 3-(2-((tert-butoxycarbonyl)amino)acetamido)-3-(3-(tert-butyl)-5-(pyrimidin-5-yl)phenyl)propanoate

(S)-ethyl 3-(3-bromo-5-(tert-butyl)phenyl)-3-(2-(3-guanidinobenzamido)acetamido)propanoate

(S)-3-(3-bromo-5-(tert-butyl)phenyl)-3-(2-(3-guanidinobenzamido)acetamido)propanoic acid

(S)-ethyl 3-(3-bromo-5-(tert-butyl)phenyl)-3-(2-(5-guanidinonicotinamido)acetamido)propanoate