tert-butyl N-[(2-chloro-3,6-difluorophenyl)methyl]carbamate

Base Information

• Chemical Name: tert-butyl N-[(2-chloro-3,6-difluorophenyl)methyl]carbamate
• CAS No.: 1394930-85-8
• Molecular Formula: C₁₂H₁₄ClF₂NO₂
• Molecular Weight: 277.698
• Mol file: 1394930-85-8.mol

Synonyms:tert-butyl N-[(2-chloro-3,6-difluorophenyl)methyl]carbamate

Chemical Property of tert-butyl N-[(2-chloro-3,6-difluorophenyl)methyl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl N-[(2-chloro-3,6-difluorophenyl)methyl]carbamate

There total 1 articles about tert-butyl N-[(2-chloro-3,6-difluorophenyl)methyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-chloro-3,6-difluorophenyl)methanamine (261762-45-2) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl N-[(2-chloro-3,6-difluorophenyl)methyl]carbamate (1394930-85-8)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1016/j.bmc.2012.07.007

Reference yield:

tert-butyl N-[(2-chloro-3,6-difluorophenyl)methyl]carbamate (1394930-85-8) → [(2-chloro-3,6-difluorophenyl)methyl](methyl)amine (1394930-91-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 18 h / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With sodium hydride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1016/j.bmc.2012.07.007

Reference yield:

tert-butyl N-[(2-chloro-3,6-difluorophenyl)methyl]carbamate (1394930-85-8) → 2-amino-5-bromo-N-[(2-chloro-3,6-difluorophenyl)methyl]-N-methylpyridine-3-carboxamide (1394930-94-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 18 h / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1016/j.bmc.2012.07.007

upstream raw materials:

(2-chloro-3,6-difluorophenyl)methanamine

di-tert-butyl dicarbonate

Downstream raw materials:

tert-butyl N-[(2-chloro-3,6-difluorophenyl)methyl]-N-methylcarbamate

[(2-chloro-3,6-difluorophenyl)methyl](methyl)amine

2-amino-5-bromo-N-[(2-chloro-3,6-difluorophenyl)methyl]-N-methylpyridine-3-carboxamide

C₁₈H₁₆ClF₂N₅O