tert-butyl N-[(2-chloro-3,6-difluorophenyl)methyl]-N-methylcarbamate

Base Information

• Chemical Name: tert-butyl N-[(2-chloro-3,6-difluorophenyl)methyl]-N-methylcarbamate
• CAS No.: 1394930-88-1
• Molecular Formula: C₁₃H₁₆ClF₂NO₂
• Molecular Weight: 291.725
• Mol file: 1394930-88-1.mol

Synonyms:tert-butyl N-[(2-chloro-3,6-difluorophenyl)methyl]-N-methylcarbamate

Chemical Property of tert-butyl N-[(2-chloro-3,6-difluorophenyl)methyl]-N-methylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl N-[(2-chloro-3,6-difluorophenyl)methyl]-N-methylcarbamate

There total 2 articles about tert-butyl N-[(2-chloro-3,6-difluorophenyl)methyl]-N-methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl N-[(2-chloro-3,6-difluorophenyl)methyl]carbamate (1394930-85-8) + methyl iodide (74-88-4) → tert-butyl N-[(2-chloro-3,6-difluorophenyl)methyl]-N-methylcarbamate (1394930-88-1)

Guidance literature:

tert-butyl N-[(2-chloro-3,6-difluorophenyl)methyl]carbamate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 18h;

DOI:10.1016/j.bmc.2012.07.007

Reference yield:

(2-chloro-3,6-difluorophenyl)methanamine (261762-45-2) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl N-[(2-chloro-3,6-difluorophenyl)methyl]-N-methylcarbamate (1394930-88-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 1 h / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 18 h / 0 - 20 °C

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

DOI:10.1016/j.bmc.2012.07.007

Reference yield:

tert-butyl N-[(2-chloro-3,6-difluorophenyl)methyl]-N-methylcarbamate (1394930-88-1) → [(2-chloro-3,6-difluorophenyl)methyl](methyl)amine (1394930-91-6)

Guidance literature:

tert-butyl N-[(2-chloro-3,6-difluorophenyl)methyl]-N-methylcarbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With sodium carbonate; In dichloromethane;

DOI:10.1016/j.bmc.2012.07.007

upstream raw materials:

(2-chloro-3,6-difluorophenyl)methanamine

di-tert-butyl dicarbonate

tert-butyl N-[(2-chloro-3,6-difluorophenyl)methyl]carbamate

methyl iodide

Downstream raw materials:

[(2-chloro-3,6-difluorophenyl)methyl](methyl)amine

2-amino-5-bromo-N-[(2-chloro-3,6-difluorophenyl)methyl]-N-methylpyridine-3-carboxamide

C₁₈H₁₆ClF₂N₅O