5-[2-(tert-butyldimethylsilanyloxy)ethyl]-5'-O-(4,4'-dimethoxytrityl)-uridine

Base Information

Chemical Name:5-[2-(tert-butyldimethylsilanyloxy)ethyl]-5'-O-(4,4'-dimethoxytrityl)-uridine
CAS No.:752232-95-4
Molecular Formula:C₃₈H₄₈N₂O₉Si
Molecular Weight:704.893
Hs Code.:

Synonyms:5-[2-(tert-butyldimethylsilanyloxy)ethyl]-5'-O-(4,4'-dimethoxytrityl)-uridine

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Chemical Property of 5-[2-(tert-butyldimethylsilanyloxy)ethyl]-5'-O-(4,4'-dimethoxytrityl)-uridine

Chemical Property:

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Technology Process of 5-[2-(tert-butyldimethylsilanyloxy)ethyl]-5'-O-(4,4'-dimethoxytrityl)-uridine

There total 5 articles about 5-[2-(tert-butyldimethylsilanyloxy)ethyl]-5'-O-(4,4'-dimethoxytrityl)-uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 752232-93-2
5-[2-(tert-butyldimethylsilanyloxy)ethyl]-uridine

: 752232-95-4
5-[2-(tert-butyldimethylsilanyloxy)ethyl]-5'-O-(4,4'-dimethoxytrityl)-uridine

Guidance literature:: With pyridine; at 20 ℃; for 19h;
DOI:10.1039/b404150j

Reference yield:

: 6974-32-9
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

: 752232-95-4
5-[2-(tert-butyldimethylsilanyloxy)ethyl]-5'-O-(4,4'-dimethoxytrityl)-uridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: hexamethyldisilazane; Me₃SiCl; SnCl₄ / acetonitrile / 16 h / 20 °C

1.2: 68 percent / imidazole / dimethylformamide / 24 h

2.1: 82 percent / NH₃ / methanol / 30 h / 20 °C

3.1: 74 percent / pyridine / 19 h / 20 °C

With pyridine; chloro-trimethyl-silane; ammonia; tin(IV) chloride; 1,1,1,3,3,3-hexamethyl-disilazane; In methanol; acetonitrile;
DOI:10.1039/b404150j

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 752232-95-4
5-[2-(tert-butyldimethylsilanyloxy)ethyl]-5'-O-(4,4'-dimethoxytrityl)-uridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 97.7 percent / imidazole / dimethylformamide / 15 h / 20 °C

2.1: hexamethyldisilazane; Me₃SiCl; SnCl₄ / acetonitrile / 16 h / 20 °C

2.2: 68 percent / imidazole / dimethylformamide / 24 h

3.1: 82 percent / NH₃ / methanol / 30 h / 20 °C

4.1: 74 percent / pyridine / 19 h / 20 °C

With pyridine; 1H-imidazole; chloro-trimethyl-silane; ammonia; tin(IV) chloride; 1,1,1,3,3,3-hexamethyl-disilazane; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/b404150j