2-tert-butoxycarbonylamino-5-(4-hydroxy-phenyl)-pent-4-ynoic acid

Base Information

• Chemical Name: 2-tert-butoxycarbonylamino-5-(4-hydroxy-phenyl)-pent-4-ynoic acid
• CAS No.: 914367-79-6
• Molecular Formula: C₁₆H₁₉NO₅
• Molecular Weight: 305.331
• Mol file: 914367-79-6.mol

Synonyms:2-tert-butoxycarbonylamino-5-(4-hydroxy-phenyl)-pent-4-ynoic acid

Chemical Property of 2-tert-butoxycarbonylamino-5-(4-hydroxy-phenyl)-pent-4-ynoic acid

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-tert-butoxycarbonylamino-5-(4-hydroxy-phenyl)-pent-4-ynoic acid

There total 1 articles about 2-tert-butoxycarbonylamino-5-(4-hydroxy-phenyl)-pent-4-ynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

p-Iodophenol (540-38-5) + 2-((tert-butoxycarbonyl)amino)pent-4-ynoic acid (61172-66-5) → 2-tert-butoxycarbonylamino-5-(4-hydroxy-phenyl)-pent-4-ynoic acid (914367-79-6)

Guidance literature:

p-Iodophenol; With copper(l) iodide; 4-diphenylphosphanobenzoic acid; caesium carbonate; palladium on activated charcoal; In water; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

2-((tert-butoxycarbonyl)amino)pent-4-ynoic acid; In water; N,N-dimethyl-formamide; at 80 ℃; for 4h;

DOI:10.1021/jo061300n

Reference yield: 96.0%

2-tert-butoxycarbonylamino-5-(4-hydroxy-phenyl)-pent-4-ynoic acid (914367-79-6) → 2-tert-butoxycarbonylamino-5-(4-hydroxy-phenyl)-pentanoic acid

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 2h;

DOI:10.1021/jo061300n

Reference yield: 86.0%

2-tert-butoxycarbonylamino-5-(4-hydroxy-phenyl)-pent-4-ynoic acid (914367-79-6) → 2-tert-butoxycarbonylamino-5-(4-hydroxy-phenyl)-pent-4-enoic acid

Guidance literature:

With hydrogen; Lindlar's catalyst; In methanol; for 11h;

DOI:10.1021/jo061300n

upstream raw materials:

p-Iodophenol

2-((tert-butoxycarbonyl)amino)pent-4-ynoic acid