Technology Process of 9,10,11-trimethoxy-6-toluenesulfonyl-6,7-dihydro-5H-dibenzo[c,e]azepine-2,3-diol
There total 6 articles about 9,10,11-trimethoxy-6-toluenesulfonyl-6,7-dihydro-5H-dibenzo[c,e]azepine-2,3-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-(3,4-dihydroxybenzyl)-4-methyl-N-(3,4,5-trimethoxybenzyl)benzenesulfonamide;
With
[bis(acetoxy)iodo]benzene;
In
1,2-dimethoxyethane;
at 0 ℃;
for 0.5h;
Inert atmosphere;
With
methanesulfonic acid;
In
1,2-dimethoxyethane;
at 0 ℃;
for 1h;
Inert atmosphere;
DOI:10.1055/s-0032-1316559
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: acetic acid; triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 20 °C / Inert atmosphere
2.1: [bis(acetoxy)iodo]benzene / 1,2-dimethoxyethane / 0.5 h / 0 °C / Inert atmosphere
2.2: 1 h / 0 °C / Inert atmosphere
With
[bis(acetoxy)iodo]benzene; acetic acid; triethylamine tris(hydrogen fluoride);
In
tetrahydrofuran; 1,2-dimethoxyethane;
DOI:10.1055/s-0032-1316559
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / diethyl ether / 2 h / 20 °C / Inert atmosphere
2.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere
4.1: acetic acid; triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 20 °C / Inert atmosphere
5.1: [bis(acetoxy)iodo]benzene / 1,2-dimethoxyethane / 0.5 h / 0 °C / Inert atmosphere
5.2: 1 h / 0 °C / Inert atmosphere
With
lithium aluminium tetrahydride; [bis(acetoxy)iodo]benzene; di-isopropyl azodicarboxylate; acetic acid; triethylamine tris(hydrogen fluoride); triethylamine; triphenylphosphine;
In
tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane;
DOI:10.1055/s-0032-1316559
