5-phenyl-3H-imidazo[4,5-b]pyridine-7-carboxylic acid (1-phenyl-propyl)-amide

Base Information

Chemical Name:5-phenyl-3H-imidazo[4,5-b]pyridine-7-carboxylic acid (1-phenyl-propyl)-amide
CAS No.:244090-23-1
Molecular Formula:C₂₂H₂₀N₄O
Molecular Weight:356.427
Hs Code.:

5-phenyl-3<i>H</i>-imidazo[4,5-<i>b</i>]pyridine-7-carboxylic acid (1-phenyl-propyl)-amide

Synonyms:5-phenyl-3H-imidazo[4,5-b]pyridine-7-carboxylic acid (1-phenyl-propyl)-amide

Suppliers and Price of 5-phenyl-3H-imidazo[4,5-b]pyridine-7-carboxylic acid (1-phenyl-propyl)-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 5-phenyl-3H-imidazo[4,5-b]pyridine-7-carboxylic acid (1-phenyl-propyl)-amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 5-phenyl-3H-imidazo[4,5-b]pyridine-7-carboxylic acid (1-phenyl-propyl)-amide

There total 5 articles about 5-phenyl-3H-imidazo[4,5-b]pyridine-7-carboxylic acid (1-phenyl-propyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 3789-59-1
(R)-1-phenylpropylamine

: 5-Phenyl-3H-imidazo[4,5-b]pyridine-7-carboxylic acid

: 244090-23-1
5-phenyl-3H-imidazo[4,5-b]pyridine-7-carboxylic acid (1-phenyl-propyl)-amide

Guidance literature:: 5-Phenyl-3H-imidazo[4,5-b]pyridine-7-carboxylic acid; With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; acetonitrile; at 20 ℃; for 1h;

(R)-1-phenylpropylamine; In tetrahydrofuran; acetonitrile; at 20 ℃; for 8h;
DOI:10.1016/S0014-827X(99)00043-9

Reference yield:

: 6296-54-4
ethyl 2,4-dioxo-4-phenylbutyrate

: 244090-23-1
5-phenyl-3H-imidazo[4,5-b]pyridine-7-carboxylic acid (1-phenyl-propyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 66 percent / ethanol / 20 h / Heating

2.1: 100 percent / H₂ / 10 percent Pd/C / ethanol; tetrahydrofuran / 22 h / 20 °C

3.1: 66 percent / 18 h / Heating

4.1: HCl; H₂O / 5 h / Heating

5.1: HOBT; Et₃N; DCC / tetrahydrofuran; acetonitrile / 1 h / 20 °C

5.2: 50 percent / tetrahydrofuran; acetonitrile / 8 h / 20 °C

With hydrogenchloride; water; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetonitrile; 1.1: Guareschi condensation / 2.1: Catalytic hydrogenation / 3.1: Condensation / 4.1: Hydrolysis / 5.1: Substitution / 5.2: Acylation;
DOI:10.1016/S0014-827X(99)00043-9

Reference yield:

: 244090-16-2
Ethyl 2-amino-3-nitro-6-phenyl-4-pyridincarboxylate

: 244090-23-1
5-phenyl-3H-imidazo[4,5-b]pyridine-7-carboxylic acid (1-phenyl-propyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 100 percent / H₂ / 10 percent Pd/C / ethanol; tetrahydrofuran / 22 h / 20 °C

2.1: 66 percent / 18 h / Heating

3.1: HCl; H₂O / 5 h / Heating

4.1: HOBT; Et₃N; DCC / tetrahydrofuran; acetonitrile / 1 h / 20 °C

4.2: 50 percent / tetrahydrofuran; acetonitrile / 8 h / 20 °C

With hydrogenchloride; water; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetonitrile; 1.1: Catalytic hydrogenation / 2.1: Condensation / 3.1: Hydrolysis / 4.1: Substitution / 4.2: Acylation;
DOI:10.1016/S0014-827X(99)00043-9