(S)-5-sec-butyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium chloride

Base Information

• Chemical Name: (S)-5-sec-butyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium chloride
• CAS No.: 1449522-19-3
• Molecular Formula: C₁₈H₂₆N₃O*Cl
• Molecular Weight: 335.877
• Mol file: 1449522-19-3.mol

Synonyms:(S)-5-sec-butyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium chloride

Chemical Property of (S)-5-sec-butyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-5-sec-butyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium chloride

There total 2 articles about (S)-5-sec-butyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-3-sec-butyl-5-methoxy-3,6-dihydro-2H-1,4-oxazine + mesitylhydrazine hydrochloride (24006-09-5,76195-82-9) + orthoformic acid triethyl ester (122-51-0) → (S)-5-sec-butyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium chloride (1449522-19-3)

Guidance literature:

(S)-3-sec-butyl-5-methoxy-3,6-dihydro-2H-1,4-oxazine; mesitylhydrazine hydrochloride; With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 24h;

orthoformic acid triethyl ester; In chlorobenzene; at 110 ℃; for 4h;

DOI:10.1055/s-0033-1338877

Reference yield:

(S)-5-sec-butylmorpholin-3-one → (S)-5-sec-butyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium chloride (1449522-19-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 24 h / 20 °C

2.1: hydrogenchloride / methanol; 1,4-dioxane / 24 h / 20 °C

2.2: 4 h / 110 °C

With hydrogenchloride; In 1,4-dioxane; methanol; dichloromethane;

DOI:10.1055/s-0033-1338877

Reference yield: 82.0%

Grubbs catalyst first generation + (S)-5-sec-butyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium chloride (1449522-19-3) → C43H64Cl2N3OPRu

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at 20 ℃; for 0.5h;

DOI:10.1055/s-0033-1338877

upstream raw materials:

mesitylhydrazine hydrochloride

orthoformic acid triethyl ester