4'-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2'-propyl-biphenyl-2-sulfonic acid (4,5-dimethyl-isoxazol-3-yl)-methoxymethyl-amide

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Chemical Name:4'-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2'-propyl-biphenyl-2-sulfonic acid (4,5-dimethyl-isoxazol-3-yl)-methoxymethyl-amide
CAS No.:1026906-58-0
Molecular Formula:C₃₄H₄₄N₄O₅S
Molecular Weight:620.813
Hs Code.:

Synonyms:4'-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2'-propyl-biphenyl-2-sulfonic acid (4,5-dimethyl-isoxazol-3-yl)-methoxymethyl-amide

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Chemical Property of 4'-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2'-propyl-biphenyl-2-sulfonic acid (4,5-dimethyl-isoxazol-3-yl)-methoxymethyl-amide

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Technology Process of 4'-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2'-propyl-biphenyl-2-sulfonic acid (4,5-dimethyl-isoxazol-3-yl)-methoxymethyl-amide

There total 7 articles about 4'-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2'-propyl-biphenyl-2-sulfonic acid (4,5-dimethyl-isoxazol-3-yl)-methoxymethyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 138402-05-8
2-butyl-1,3-diaza-spiro[4.4]non-1-en-4one

: 1026924-98-0
4'-bromomethyl-2'-propyl-biphenyl-2-sulfonic acid (4,5-dimethyl-isoxazol-3-yl)-methoxymethyl-amide

: 1026906-58-0
4'-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2'-propyl-biphenyl-2-sulfonic acid (4,5-dimethyl-isoxazol-3-yl)-methoxymethyl-amide

Guidance literature:: 2-butyl-1,3-diaza-spiro[4.4]non-1-en-4one; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

4'-bromomethyl-2'-propyl-biphenyl-2-sulfonic acid (4,5-dimethyl-isoxazol-3-yl)-methoxymethyl-amide; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm049548x

Reference yield:

: 89003-95-2
3-formaldehyde-4-bromobenzonitrile

: 1026906-58-0
4'-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2'-propyl-biphenyl-2-sulfonic acid (4,5-dimethyl-isoxazol-3-yl)-methoxymethyl-amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-BuLi / tetrahydrofuran; diethyl ether; hexane / 3 h / 20 °C

1.2: tetrahydrofuran; diethyl ether; hexane / 16 h / 20 °C

2.1: PtO₂; H₂ / ethanol / 0.67 h / 1810.02 Torr

3.1: 1.3 g / DIBAL-H / toluene / 2 h / 20 °C

4.1: Pd(PPh₃)4; aq. Na₂CO₃ / aq. ethanol; toluene / 85 °C

5.1: NaBH₄ / methanol / 20 °C

6.1: CBr₄; PPh₃ / dimethylformamide / 0 °C

7.1: NaH / dimethylformamide / 20 °C

7.2: dimethylformamide / 20 °C

With platinum(IV) oxide; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; carbon tetrabromide; hydrogen; sodium hydride; diisobutylaluminium hydride; sodium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; N,N-dimethyl-formamide; toluene; 1.2: Witting olefination / 4.1: Suzuki coupling;
DOI:10.1021/jm049548x

Reference yield:

: 254745-39-6
4-bromo-3-propylbenzaldehyde

: 1026906-58-0
4'-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2'-propyl-biphenyl-2-sulfonic acid (4,5-dimethyl-isoxazol-3-yl)-methoxymethyl-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: Pd(PPh₃)4; aq. Na₂CO₃ / aq. ethanol; toluene / 85 °C

2.1: NaBH₄ / methanol / 20 °C

3.1: CBr₄; PPh₃ / dimethylformamide / 0 °C

4.1: NaH / dimethylformamide / 20 °C

4.2: dimethylformamide / 20 °C

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; sodium hydride; sodium carbonate; triphenylphosphine; In methanol; ethanol; N,N-dimethyl-formamide; toluene; 1.1: Suzuki coupling;
DOI:10.1021/jm049548x