(2R,1'R,2'R)-2-(2'-benzyloxymethyl-3',3'-difluoro)cyclopropyl-2-azidoethyl tert-butyldimethylsilyl ether

Base Information

Chemical Name:(2R,1'R,2'R)-2-(2'-benzyloxymethyl-3',3'-difluoro)cyclopropyl-2-azidoethyl tert-butyldimethylsilyl ether
CAS No.:174173-95-6
Molecular Formula:C₁₉H₂₉F₂N₃O₂Si
Molecular Weight:397.54
Hs Code.:

Synonyms:(2R,1'R,2'R)-2-(2'-benzyloxymethyl-3',3'-difluoro)cyclopropyl-2-azidoethyl tert-butyldimethylsilyl ether

Suppliers and Price of (2R,1'R,2'R)-2-(2'-benzyloxymethyl-3',3'-difluoro)cyclopropyl-2-azidoethyl tert-butyldimethylsilyl ether

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,1'R,2'R)-2-(2'-benzyloxymethyl-3',3'-difluoro)cyclopropyl-2-azidoethyl tert-butyldimethylsilyl ether

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,1'R,2'R)-2-(2'-benzyloxymethyl-3',3'-difluoro)cyclopropyl-2-azidoethyl tert-butyldimethylsilyl ether

There total 5 articles about (2R,1'R,2'R)-2-(2'-benzyloxymethyl-3',3'-difluoro)cyclopropyl-2-azidoethyl tert-butyldimethylsilyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 174173-94-5
(S)-1-((1R,3R)-3-Benzyloxymethyl-2,2-difluoro-cyclopropyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethanol

: 174173-95-6
(2R,1'R,2'R)-2-(2'-benzyloxymethyl-3',3'-difluoro)cyclopropyl-2-azidoethyl tert-butyldimethylsilyl ether

Guidance literature:: With diphenylphosphoranyl azide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 6h; Ambient temperature;
DOI:10.1016/0040-4020(95)00870-E

Reference yield:

: 158800-64-7
(S)-4-((1R,3R)-3-Benzyloxymethyl-2,2-difluoro-cyclopropyl)-2,2-dimethyl-[1,3]dioxolane

: 174173-95-6
(2R,1'R,2'R)-2-(2'-benzyloxymethyl-3',3'-difluoro)cyclopropyl-2-azidoethyl tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 3 steps

1: HCl / methanol

2: imidazole

3: (PhO)2P(O)N₃, DEAD, Ph₃P

With 1H-imidazole; hydrogenchloride; diphenyl phosphoryl azide; triphenylphosphine; diethylazodicarboxylate; In methanol;
DOI:10.1016/S0960-894X(98)00338-2

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 174173-95-6
(2R,1'R,2'R)-2-(2'-benzyloxymethyl-3',3'-difluoro)cyclopropyl-2-azidoethyl tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: imidazole

2: (PhO)2P(O)N₃, DEAD, Ph₃P

With 1H-imidazole; diphenyl phosphoryl azide; triphenylphosphine; diethylazodicarboxylate;
DOI:10.1016/S0960-894X(98)00338-2