Technology Process of Boc-Lys(4-[1-{2,2,6,6-tetramethylpiperidin-1-yloxy}ethyl]benzoyl)-Gly-OH
There total 9 articles about Boc-Lys(4-[1-{2,2,6,6-tetramethylpiperidin-1-yloxy}ethyl]benzoyl)-Gly-OH which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Boc-Lys(4-[1-{2,2,6,6-tetramethylpiperidin-1-yloxy}ethyl]benzoyl)-Gly-OMe;
With
sodium hydroxide;
In
methanol; water;
at 20 ℃;
for 16h;
Inert atmosphere;
With
hydrogenchloride;
In
methanol; dichloromethane; water;
at 20 ℃;
Inert atmosphere;
DOI:10.1039/c0ob01047b
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C / Inert atmosphere
2.1: sodium hydroxide / methanol; water / 16 h / 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
With
4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide;
In
methanol; dichloromethane; water;
DOI:10.1039/c0ob01047b
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.33 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C
1.3: 20 °C
2.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C / Inert atmosphere
3.1: sodium hydroxide / methanol; water / 16 h / 20 °C / Inert atmosphere
3.2: 20 °C / Inert atmosphere
With
4-methyl-morpholine; tert.-butyl lithium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; pentane;
DOI:10.1039/c0ob01047b