(R)-ethyl 3-((2-(4-(2-fluoro-4-(5-((4-methyl-1H-1,2,3-triazol-1-yl)methyl)-2-oxo oxazolidin-3-yl)phenyl)piperazin-1-yl)-2-oxoethyl)amino)-3-oxopropanoate

Base Information

Chemical Name:(R)-ethyl 3-((2-(4-(2-fluoro-4-(5-((4-methyl-1H-1,2,3-triazol-1-yl)methyl)-2-oxo oxazolidin-3-yl)phenyl)piperazin-1-yl)-2-oxoethyl)amino)-3-oxopropanoate
CAS No.:1448996-66-4
Molecular Formula:C₂₄H₃₀FN₇O₆
Molecular Weight:531.544
Hs Code.:

Synonyms:(R)-ethyl 3-((2-(4-(2-fluoro-4-(5-((4-methyl-1H-1,2,3-triazol-1-yl)methyl)-2-oxo oxazolidin-3-yl)phenyl)piperazin-1-yl)-2-oxoethyl)amino)-3-oxopropanoate

Suppliers and Price of (R)-ethyl 3-((2-(4-(2-fluoro-4-(5-((4-methyl-1H-1,2,3-triazol-1-yl)methyl)-2-oxo oxazolidin-3-yl)phenyl)piperazin-1-yl)-2-oxoethyl)amino)-3-oxopropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-ethyl 3-((2-(4-(2-fluoro-4-(5-((4-methyl-1H-1,2,3-triazol-1-yl)methyl)-2-oxo oxazolidin-3-yl)phenyl)piperazin-1-yl)-2-oxoethyl)amino)-3-oxopropanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-ethyl 3-((2-(4-(2-fluoro-4-(5-((4-methyl-1H-1,2,3-triazol-1-yl)methyl)-2-oxo oxazolidin-3-yl)phenyl)piperazin-1-yl)-2-oxoethyl)amino)-3-oxopropanoate

There total 5 articles about (R)-ethyl 3-((2-(4-(2-fluoro-4-(5-((4-methyl-1H-1,2,3-triazol-1-yl)methyl)-2-oxo oxazolidin-3-yl)phenyl)piperazin-1-yl)-2-oxoethyl)amino)-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1071-46-1
hydrogen ethyl malonate

: 1417179-95-3
(R)-2-(4-(2-fluoro-4-(5-((4-methyl-1H-1,2,3-triazol-1-yl)methyl)-2-oxo-oxazolidin-3-yl)phenyl)piperazin-1-yl)-2-oxoethanaminium 2,2,2-trifluoroacetate

: 1448996-66-4
(R)-ethyl 3-((2-(4-(2-fluoro-4-(5-((4-methyl-1H-1,2,3-triazol-1-yl)methyl)-2-oxo oxazolidin-3-yl)phenyl)piperazin-1-yl)-2-oxoethyl)amino)-3-oxopropanoate

Guidance literature:: With oxalyl dichloride; triethylamine; In dichloromethane; acetonitrile; at 0 - 20 ℃;
DOI:10.1016/j.ejmech.2013.05.041

Reference yield:

: 154590-64-4
(S)-N-[3-[3-fluoro-4-[N-t-butoxycarbonylpiperazin-1-yl]phenyl]-2-oxooxazolidin-5-ylmethyl]azide

: 1448996-66-4
(R)-ethyl 3-((2-(4-(2-fluoro-4-(5-((4-methyl-1H-1,2,3-triazol-1-yl)methyl)-2-oxo oxazolidin-3-yl)phenyl)piperazin-1-yl)-2-oxoethyl)amino)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / methanol / 0 - 20 °C

2.1: dichloromethane / 0 - 20 °C

3.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: dichloromethane / 0 - 20 °C

5.1: triethylamine; oxalyl dichloride / acetonitrile; dichloromethane / 0 - 20 °C

With oxalyl dichloride; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.ejmech.2013.05.041

Reference yield:

: 1170353-88-4
tert-butyl 4-(2-fluoro-4-((R)-5-((4-methyl-1H-1,2,3-triazol-1-yl)methyl)-2-oxooxazolidin-3-yl)phenyl)piperazine-1-carboxylate

: 1448996-66-4
(R)-ethyl 3-((2-(4-(2-fluoro-4-(5-((4-methyl-1H-1,2,3-triazol-1-yl)methyl)-2-oxo oxazolidin-3-yl)phenyl)piperazin-1-yl)-2-oxoethyl)amino)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 0 - 20 °C

2.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: dichloromethane / 0 - 20 °C

4.1: triethylamine; oxalyl dichloride / acetonitrile; dichloromethane / 0 - 20 °C

With oxalyl dichloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; acetonitrile;
DOI:10.1016/j.ejmech.2013.05.041