(1′S,5α,6R,7R,14α)-1′-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-17-cyclopropylmethyl-6,14-ethenomorphinan-7-yl)-1′-phenylmethanol hydrochloride

Base Information

Chemical Name:(1′S,5α,6R,7R,14α)-1′-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-17-cyclopropylmethyl-6,14-ethenomorphinan-7-yl)-1′-phenylmethanol hydrochloride
CAS No.:1609379-25-0
Molecular Formula:C₃₀H₃₃NO₄*ClH
Molecular Weight:508.057
Hs Code.:

Synonyms:(1′S,5α,6R,7R,14α)-1′-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-17-cyclopropylmethyl-6,14-ethenomorphinan-7-yl)-1′-phenylmethanol hydrochloride

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Chemical Property of (1′S,5α,6R,7R,14α)-1′-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-17-cyclopropylmethyl-6,14-ethenomorphinan-7-yl)-1′-phenylmethanol hydrochloride

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Technology Process of (1′S,5α,6R,7R,14α)-1′-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-17-cyclopropylmethyl-6,14-ethenomorphinan-7-yl)-1′-phenylmethanol hydrochloride

There total 5 articles about (1′S,5α,6R,7R,14α)-1′-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-17-cyclopropylmethyl-6,14-ethenomorphinan-7-yl)-1′-phenylmethanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1609379-20-5
N-cyclopropylmethylnorisonepenthol

: 1609379-25-0
(1′S,5α,6R,7R,14α)-1′-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-17-cyclopropylmethyl-6,14-ethenomorphinan-7-yl)-1′-phenylmethanol hydrochloride

Guidance literature:: N-cyclopropylmethylnorisonepenthol; With N,N,N,N,N,N-hexamethylphosphoric triamide; 1-thiopropane; sodium hydride; for 3h; Inert atmosphere; Heating;

With hydrogenchloride; In diethyl ether; Inert atmosphere;
DOI:10.1021/jm401964y

Reference yield: 76.0%

: N-cyclopropylmethylnornepenthol

: 1609379-25-0
(1′S,5α,6R,7R,14α)-1′-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-17-cyclopropylmethyl-6,14-ethenomorphinan-7-yl)-1′-phenylmethanol hydrochloride

Guidance literature:: N-cyclopropylmethylnornepenthol; With N,N,N,N,N,N-hexamethylphosphoric triamide; 1-thiopropane; sodium hydride; for 3h; Inert atmosphere; Heating;

With hydrogenchloride; In diethyl ether; Inert atmosphere;
DOI:10.1021/jm401964y

Reference yield:

: 100-58-3
phenylmagnesium bromide

: 1609379-25-0
(1′S,5α,6R,7R,14α)-1′-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-17-cyclopropylmethyl-6,14-ethenomorphinan-7-yl)-1′-phenylmethanol hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene; tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

2.1: N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride; 1-thiopropane / 3 h / Inert atmosphere; Heating

2.2: Inert atmosphere

With N,N,N,N,N,N-hexamethylphosphoric triamide; 1-thiopropane; sodium hydride; In tetrahydrofuran; toluene;
DOI:10.1021/jm401964y