3-[(1S,3S,5R)-8-(4-Amino-cyclohexylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-1H-indol-5-ol

Base Information

Chemical Name:3-[(1S,3S,5R)-8-(4-Amino-cyclohexylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-1H-indol-5-ol
CAS No.:374088-23-0
Molecular Formula:C₂₂H₃₁N₃O
Molecular Weight:353.508
Hs Code.:

Synonyms:3-[(1S,3S,5R)-8-(4-Amino-cyclohexylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-1H-indol-5-ol

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Chemical Property of 3-[(1S,3S,5R)-8-(4-Amino-cyclohexylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-1H-indol-5-ol

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Technology Process of 3-[(1S,3S,5R)-8-(4-Amino-cyclohexylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-1H-indol-5-ol

There total 6 articles about 3-[(1S,3S,5R)-8-(4-Amino-cyclohexylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-1H-indol-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 374088-22-9
{4-[3-(5-hydroxy-1H-indol-3-yl)-8-aza-bicyclo[3.2.1]oct-8-ylmethyl]-cyclohexyl}-carbamic acid tert-butyl ester

: 374088-23-0
3-[(1S,3S,5R)-8-(4-Amino-cyclohexylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-1H-indol-5-ol

Guidance literature:: With hydrogenchloride; In ethanol;
DOI:10.1016/S0960-894X(01)00397-3

Reference yield:

: 53292-90-3
cis-4-tert-butoxycarbonylaminocyclohexane-1-ylcarboxylic acid

: 374088-23-0
3-[(1S,3S,5R)-8-(4-Amino-cyclohexylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-1H-indol-5-ol

Guidance literature:: Multi-step reaction with 5 steps

1: TEA

2: NaBH₄

3: 96 percent / DMSO; (COCl)2; TEA

4: 40 percent / NaHB(OAc)3

5: 100 percent / HCl / ethanol

With hydrogenchloride; sodium tetrahydroborate; oxalyl dichloride; TEA; sodium tris(acetoxy)borohydride; dimethyl sulfoxide; In ethanol;
DOI:10.1016/S0960-894X(01)00397-3

Reference yield:

: 3685-23-2
cis-4-aminocyclohexane-1-carboxylic acid

: 374088-23-0
3-[(1S,3S,5R)-8-(4-Amino-cyclohexylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-1H-indol-5-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / TEA

2: TEA

3: NaBH₄

4: 96 percent / DMSO; (COCl)2; TEA

5: 40 percent / NaHB(OAc)3

6: 100 percent / HCl / ethanol

With hydrogenchloride; sodium tetrahydroborate; oxalyl dichloride; TEA; sodium tris(acetoxy)borohydride; dimethyl sulfoxide; In ethanol;
DOI:10.1016/S0960-894X(01)00397-3