53292-90-3

Basic information

• Product Name: CIS-4-(BOC-AMINO)CYCLOHEXANECARBOXYLIC ACID
• Synonyms: cis-1-(t-butyloxycarbonyl-amino)-cyclohexyl-4-carboxylicacid;(1s,4s)-4-(tert-butoxycarbonylamino)cyclohexanecarboxylic acid;trans-4-tert-butoxycarbonylaMinocyclohexane-1-ylcarboxylic acid;cis-4-[(tert-Butyloxycarbonyl)amino]cyclohexanecarboxylic acid;cis-4-[[[(1,1-Dimethylethyl)oxy]carbonyl]amino]cyclohexanecarboxylic acid;cis-4-tert-Butoxycarbonylamino-1-cyclohexanecarboxylic acid;N-BOC-cis-4-Aminocyclohexane-1-carboxylic acid;cis-4-(tert-Butoxycarbonylamino)cyclohexanecarboxylic Acid
• CAS NO: 53292-90-3
• Molecular Formula: C₁₂H₂₁NO₄
• Molecular Weight: 243.3
• Product Categories: Alicyclic Amino Acids;Peptide Synthesis;Unnatural Amino Acid Derivatives
• Mol File: 53292-90-3.mol
• Article Data: 27

Chemical Properties

• Melting Point: 169°C(lit.)
• Boiling Point: 396.698 °C at 760 mmHg
• Flash Point: 193.716 °C
• Appearance: White to off-white/Powder
• Density: 1.13 g/cm³
• Vapor Pressure: 2.12E-07mmHg at 25°C
• Refractive Index: 1.493
• Storage Temp.: 2-8°C
• PKA: 4.89±0.25(Predicted)
• BRN: 7641071
• CAS DataBase Reference: CIS-4-(BOC-AMINO)CYCLOHEXANECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: CIS-4-(BOC-AMINO)CYCLOHEXANECARBOXYLIC ACID(53292-90-3)
• EPA Substance Registry System: CIS-4-(BOC-AMINO)CYCLOHEXANECARBOXYLIC ACID(53292-90-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 53292-90-3(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C12H21NO4/c1-12(2,3)17-11(16)13-9-6-4-8(5-7-9)10(14)15/h8-9H,4-7H2,1-3H3,(H,13,16)(H,14,15)/t8-,9+

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1776-53-0 trans-4-aminocyclohexanecarboxylic acid 
• 881657-40-5 tert-butyl ((3R,6S)-6-formyltetrahydro-2H-pyran-3-yl)carbamate 
• 1776-53-0 4-aminocyclohexanecarboxylic acid 
• 150-13-0 4-amino-benzoic acid 
• 3685-23-2 cis-4-aminocyclohexane-1-carboxylic acid 
• 6297-22-9 4-carbomethoxycyclohexanone 
• 38446-95-6 4-oxocyclohexanecarboxylic acid tert-butyl ester 
• 400899-07-2 methyl (1r,4r)‐4‐{[(tert‐butoxy)carbonyl](methyl)amino}cyclohexane‐1‐carboxylate 
• 603130-12-7 1,5-anhydro-2-[(tert-butoxycarbonyl)amino]-2,3,4-trideoxy-D-erythro-hexitol 
• 146307-51-9 methyl (1R,4R)-4-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate 
• 17159-79-4 ethyl 4-oxocyclohexane-1-carboxylate 

Downstream Products

• 133075-92-0 N<carbonyl>phenylalanine benzyl ester 
• 364385-64-8 cis-4-(tert-butoxycarbonylamino)cyclohexanecarboxylic acid methyl ester 
• 509143-03-7 cis-(4-tert-butoxycarbonylamino-cyclohexyl)-carbamic acid benzyl ester 
• 239074-29-4 trans (4-hydroxymethyl-cyclohexyl)-carbamic acid tert-butyl ester 
• 615568-05-3 C₂₁H₂₈N₄O₄ 
• 1456507-48-4 tert-butyl ((1r,4r)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)cyclohexyl)carbamate 

Relevant articles and documents

PYRIMIDINYL GROUP-CONTAINING TRICYCLIC COMPOUND SERVING AS C-MET INHIBITOR

Disclosed are a pyrimidinyl group-containing tricyclic compound and applications thereof in preparing a cancer-treating medicament. Specifically disclosed are a compound as represented by formula (I), a pharmaceutically acceptable salt of same, or an isomer thereof.

Discovery of Hydroxyamidine Derivatives as Highly Potent, Selective Indoleamine-2,3-dioxygenase 1 Inhibitors

In this study, a series of novel hydroxyamidine derivatives were identified as potent and selective IDO1 inhibitors by structure-based drug design. Among them, compounds 13-15 and 18 exhibited favorable enzymatic and cellular activities. Compound 18 showed improved bioavailability in mouse, rat, and dog (F% = 44%, 58.8%, 102.1%, respectively). With reasonable in vivo pharmacokinetic properties, compound 18 was further evaluated in a transgenic MC38 xenograft mouse model. The combination of compound 18 with PD-1 monoclonal antibody showed a synergistic antitumor effect. These data indicated that compound 18 as a potential cancer immunotherapy agent should warrant further investigation.

Compound serving as protein kinase inhibitor and application of compound

The invention discloses a compound used as a protein kinase inhibitor and application of the compound, the compound has an obvious inhibition effect on protein kinase activity, can be used as a BTK inhibitor for preparing medicines for treating BTK-mediated diseases such as malignant tumors, autoimmune diseases and the like, and has wide application prospect.