(2R)-[N-(tert-butoxycarbonyl)-2-aminobut-(Z)-ylidene]benzylamine N-oxide

Base Information

• Chemical Name: (2R)-[N-(tert-butoxycarbonyl)-2-aminobut-(Z)-ylidene]benzylamine N-oxide
• CAS No.: 856781-70-9
• Molecular Formula: C₁₆H₂₄N₂O₃
• Molecular Weight: 292.378

Synonyms:(2R)-[N-(tert-butoxycarbonyl)-2-aminobut-(Z)-ylidene]benzylamine N-oxide

Chemical Property of (2R)-[N-(tert-butoxycarbonyl)-2-aminobut-(Z)-ylidene]benzylamine N-oxide

Chemical Property:

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Technology Process of (2R)-[N-(tert-butoxycarbonyl)-2-aminobut-(Z)-ylidene]benzylamine N-oxide

There total 3 articles about (2R)-[N-(tert-butoxycarbonyl)-2-aminobut-(Z)-ylidene]benzylamine N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

N-benzyl hydroxylalmine (622-30-0) + (2R)-N-(tert-butoxycarbonyl)-2-aminobutanal (856781-69-6) → (2R)-[N-(tert-butoxycarbonyl)-2-aminobut-(Z)-ylidene]benzylamine N-oxide (856781-70-9)

Guidance literature:

With magnesium sulfate; In dichloromethane; at 20 ℃; for 15h;

DOI:10.1002/ardp.200400621

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (2R)-[N-(tert-butoxycarbonyl)-2-aminobut-(Z)-ylidene]benzylamine N-oxide (856781-70-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

2: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -60 - 20 °C

3: 66 percent / MgSO₄ / CH₂Cl₂ / 15 h / 20 °C

With oxalyl dichloride; magnesium sulfate; dimethyl sulfoxide; triethylamine; In dichloromethane;

DOI:10.1002/ardp.200400621

Reference yield:

tert-butyl (R)-(1-hydroxybutan-2-yl)carbamate (150736-71-3) → (2R)-[N-(tert-butoxycarbonyl)-2-aminobut-(Z)-ylidene]benzylamine N-oxide (856781-70-9)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -60 - 20 °C

2: 66 percent / MgSO₄ / CH₂Cl₂ / 15 h / 20 °C

With oxalyl dichloride; magnesium sulfate; dimethyl sulfoxide; triethylamine; In dichloromethane;

DOI:10.1002/ardp.200400621

upstream raw materials:

N-benzyl hydroxylalmine

(2R)-N-(tert-butoxycarbonyl)-2-aminobutanal

di-tert-butyl dicarbonate

tert-butyl (R)-(1-hydroxybutan-2-yl)carbamate

Downstream raw materials:

(1R,2R)-N¹-benzyl-N²-(tert-butoxycarbonyl)-2-amino-1-(4-fluorophenyl)-N¹-hydroxy-aminobutane

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