N-Boc-(R)-(+)-2-amino-1-butanol

Base Information

• Chemical Name: N-Boc-(R)-(+)-2-amino-1-butanol
• CAS No.: 150736-71-3
• Molecular Formula: C9H19 N O3
• Molecular Weight: 189.255
• Hs Code.: 2924199090
• European Community (EC) Number: 693-773-4
• DSSTox Substance ID: DTXSID50465741
• Nikkaji Number: J756.439B
• Wikidata: Q82291936
• Mol file: 150736-71-3.mol

Synonyms:150736-71-3;N-Boc-(R)-(+)-2-amino-1-butanol;(R)-tert-Butyl (1-hydroxybutan-2-yl)carbamate;tert-butyl N-[(2R)-1-hydroxybutan-2-yl]carbamate;tert-Butyl (R)-(1-hydroxybutan-2-yl)carbamate;Carbamic acid, [(1R)-1-(hydroxymethyl)propyl]-, 1,1-dimethylethyl ester (9CI);Carbamic acid, N-[(1R)-1-(hydroxymethyl)propyl]-, 1,1-dimethylethyl ester;SCHEMBL1809285;DTXSID50465741;N-Boc-(R)-2-amino-1-butanol;LQRGWGOFPUXNOV-SSDOTTSWSA-N;MFCD04974273;AKOS025294564;AS-43354;(2R)-2-tert-butoxycarbonylamino-1-butanol;(R)-tert-butyl 1-hydroxybutan-2-ylcarbamate;CS-0094053;(R)-tert-butyl 1-hydroxybutan-2-yl-carbamate;N-Boc-(R)-(+)-2-amino-1-butanol, 96%;(R)-tert-Butyl(1-hydroxybutan-2-yl)carbamate;EN300-299844;J-008733;((R)-1-Hydroxymethyl-propyl)-carbamic acid tert-butyl ester

Chemical Property of N-Boc-(R)-(+)-2-amino-1-butanol

Chemical Property:

• Melting Point: 40-45°C
• PSA: 62.05000
• LogP: 1.48640
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 189.13649347
• Heavy Atom Count: 13
• Complexity: 163

Purity/Quality:

97% ^*data from raw suppliers

N-Boc-(R)-2-amino-1-butanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 22-34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(CO)NC(=O)OC(C)(C)C
• Isomeric SMILES: CC[C@H](CO)NC(=O)OC(C)(C)C

Technology Process of N-Boc-(R)-(+)-2-amino-1-butanol

There total 1 articles about N-Boc-(R)-(+)-2-amino-1-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1-hydroxymethyl-propenyl)-carbamic acid tert-butyl ester (251325-57-2) → (S)-tert-butyl 1-hydroxybutan-2-ylcarbamate (150736-72-4) + tert-butyl (R)-(1-hydroxybutan-2-yl)carbamate (150736-71-3)

Guidance literature:

With hydrogen; (+)-1,2-bis-((2S,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium(I) trifluoromethanesulfonate; In tetrahydrofuran; at 20 - 25 ℃; for 12h; under 1551.44 Torr; Title compound not separated from byproducts;

DOI:10.1016/S0040-4039(99)01376-3

Reference yield: 100.0%

p-toluenesulfonyl chloride (98-59-9) + tert-butyl (R)-(1-hydroxybutan-2-yl)carbamate (150736-71-3) → (R)-N-Boc-2-aminobutanol tosylate (400090-59-7)

Guidance literature:

With pyridine; at -4 ℃; for 72h;

DOI:10.1021/np0102253

Reference yield: 100.0%

methanesulfonyl chloride (124-63-0) + tert-butyl (R)-(1-hydroxybutan-2-yl)carbamate (150736-71-3) → methanesulfonic acid (R)-2-tert-butoxycarbonylaminobutyl ester (474645-98-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/chem.201602884

upstream raw materials:

(1-hydroxymethyl-propenyl)-carbamic acid tert-butyl ester

Downstream raw materials:

methanesulfonic acid (R)-2-tert-butoxycarbonylaminobutyl ester

(2R)-2-aminobutan-1-ol

(R)-N-Boc-2-aminobutanol tosylate

(2R)-[N-(tert-butoxycarbonyl)-2-aminobut-(Z)-ylidene]benzylamine N-oxide