(2R,3R)-2-(4-allyl-2,6-dimethoxyphenoxy)-3-hydroxy-3-(3,4,5-trimethoxyphenyl)propyl-4-methylbenzenesulfonate

Base Information

Chemical Name:(2R,3R)-2-(4-allyl-2,6-dimethoxyphenoxy)-3-hydroxy-3-(3,4,5-trimethoxyphenyl)propyl-4-methylbenzenesulfonate
CAS No.:1395081-68-1
Molecular Formula:C₃₀H₃₆O₁₀S
Molecular Weight:588.676
Hs Code.:

Synonyms:(2R,3R)-2-(4-allyl-2,6-dimethoxyphenoxy)-3-hydroxy-3-(3,4,5-trimethoxyphenyl)propyl-4-methylbenzenesulfonate

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Chemical Property of (2R,3R)-2-(4-allyl-2,6-dimethoxyphenoxy)-3-hydroxy-3-(3,4,5-trimethoxyphenyl)propyl-4-methylbenzenesulfonate

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Technology Process of (2R,3R)-2-(4-allyl-2,6-dimethoxyphenoxy)-3-hydroxy-3-(3,4,5-trimethoxyphenyl)propyl-4-methylbenzenesulfonate

There total 7 articles about (2R,3R)-2-(4-allyl-2,6-dimethoxyphenoxy)-3-hydroxy-3-(3,4,5-trimethoxyphenyl)propyl-4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1395081-65-8
(1R,2R)-2-(4-allyl-2,6-dimethoxyphenoxy)-1-(3,4,5-trimethoxyphenyl)propane-1,3-diol

: 98-59-9
p-toluenesulfonyl chloride

: 1395081-68-1
(2R,3R)-2-(4-allyl-2,6-dimethoxyphenoxy)-3-hydroxy-3-(3,4,5-trimethoxyphenyl)propyl-4-methylbenzenesulfonate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1055/s-0031-1290678

Reference yield:

: 500889-82-7
2-(4-allyl-2,6-dimethoxyphenoxy)acetic acid

: 1395081-68-1
(2R,3R)-2-(4-allyl-2,6-dimethoxyphenoxy)-3-hydroxy-3-(3,4,5-trimethoxyphenyl)propyl-4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; toluene / 0.33 h / 0 °C / Inert atmosphere

2.2: 3.33 h / -78 - 20 °C / Inert atmosphere

3.1: di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 0.25 h / 0 - 20 °C / Inert atmosphere

3.2: 0.5 h / 20 °C / Inert atmosphere

3.3: 4.75 h / -78 - 0 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / diethyl ether / 2 h / 20 °C / Inert atmosphere

5.1: dmap; triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With dmap; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; di-n-butylboryl trifluoromethanesulfonate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; 3.1: Aldol condensation / 3.2: Aldol condensation / 3.3: Aldol condensation;
DOI:10.1055/s-0031-1290678

Reference yield:

: 1395081-59-0
(S)-3-(2-(4-allyl-2,6-dimethoxyphenoxy)acetyl)-4-isopropyl-5,5-diphenyloxazolidin-2-one

: 1395081-68-1
(2R,3R)-2-(4-allyl-2,6-dimethoxyphenoxy)-3-hydroxy-3-(3,4,5-trimethoxyphenyl)propyl-4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 0.25 h / 0 - 20 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

1.3: 4.75 h / -78 - 0 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / diethyl ether / 2 h / 20 °C / Inert atmosphere

3.1: dmap; triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With dmap; lithium aluminium tetrahydride; di-n-butylboryl trifluoromethanesulfonate; triethylamine; In diethyl ether; dichloromethane; 1.1: Aldol condensation / 1.2: Aldol condensation / 1.3: Aldol condensation;
DOI:10.1055/s-0031-1290678