N-[2-benzyloxycarbonylamino-3-(3,5-di-tert-butyl-1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)propionyl]leucine ethyl ester

Base Information

Chemical Name:N-[2-benzyloxycarbonylamino-3-(3,5-di-tert-butyl-1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)propionyl]leucine ethyl ester
CAS No.:212135-51-8
Molecular Formula:C₃₃H₄₈N₂O₇
Molecular Weight:584.753
Hs Code.:

Synonyms:N-[2-benzyloxycarbonylamino-3-(3,5-di-tert-butyl-1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)propionyl]leucine ethyl ester

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Chemical Property of N-[2-benzyloxycarbonylamino-3-(3,5-di-tert-butyl-1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)propionyl]leucine ethyl ester

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Technology Process of N-[2-benzyloxycarbonylamino-3-(3,5-di-tert-butyl-1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)propionyl]leucine ethyl ester

There total 2 articles about N-[2-benzyloxycarbonylamino-3-(3,5-di-tert-butyl-1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)propionyl]leucine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 2743-60-4,75023-21-1
L-Leucine ethyl ester

: 212135-44-9
(7,9-Di-tert-butyl-2,8-dioxo-1-oxa-spiro[4.5]deca-6,9-dien-3-yl)-carbamic acid benzyl ester

: 212135-51-8
N-[2-benzyloxycarbonylamino-3-(3,5-di-tert-butyl-1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)propionyl]leucine ethyl ester

Guidance literature:: toluene-4-sulfonic acid; In chloroform; at 60 ℃; for 80h;
DOI:10.1039/a801803k

Reference yield:

: 2-Benzyloxycarbonylamino-3-(3,5-di-tert-butyl-4-hydroxy-phenyl)-propionic acid

: 212135-51-8
N-[2-benzyloxycarbonylamino-3-(3,5-di-tert-butyl-1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)propionyl]leucine ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / NBS, acetate buffer (pH 4.6) / acetonitrile

2: 67 percent / p-TsOH / CHCl₃ / 80 h / 60 °C

With N-Bromosuccinimide; acetate buffer; toluene-4-sulfonic acid; In chloroform; acetonitrile;
DOI:10.1039/a801803k