7-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

Base Information

• Chemical Name: 7-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine
• CAS No.: 1253800-44-0
• Molecular Formula: C₁₄H₁₁ClF₃N₃O
• Molecular Weight: 329.709

Synonyms:7-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

Chemical Property of 7-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

Chemical Property:

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Technology Process of 7-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

There total 1 articles about 7-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.4%

2-chloro-3-(trifluoromethyl)benzoyl chloride (850156-39-7) + tetrahydro-5,6,7,8 imidazo<1,2-a>pyrazine (91476-80-1) → 7-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (1253800-44-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 5h;

Reference yield: 4.59%

7-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (1253800-44-0) → 7-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-iodo-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (1253800-64-4) + 7-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-2,3-diiodo-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (1253800-63-3)

Guidance literature:

With N-iodo-succinimide; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

2-methylphenyl bromide (95-46-5) + 7-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (1253800-44-0) → 7-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(2-methylphenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (1253801-19-2)

Guidance literature:

With caesium carbonate; palladium diacetate; triethylamine; In 1,4-dioxane; at 90 ℃; for 16h; Inert atmosphere;

upstream raw materials:

2-chloro-3-(trifluoromethyl)benzoyl chloride

tetrahydro-5,6,7,8 imidazo<1,2-a>pyrazine

Downstream raw materials:

7-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(2-methylphenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

3-bromo-7-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

7-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-iodo-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

7-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-2,3-diiodo-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

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