(R)-2-Oxo-5-phenyl-cyclopentanecarboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Base Information

Chemical Name:(R)-2-Oxo-5-phenyl-cyclopentanecarboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester
CAS No.:167304-71-4
Molecular Formula:C₂₈H₃₄O₃
Molecular Weight:418.576
Hs Code.:

Synonyms:(R)-2-Oxo-5-phenyl-cyclopentanecarboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

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Chemical Property of (R)-2-Oxo-5-phenyl-cyclopentanecarboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

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Technology Process of (R)-2-Oxo-5-phenyl-cyclopentanecarboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

There total 3 articles about (R)-2-Oxo-5-phenyl-cyclopentanecarboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 591-51-5
phenyllithium

: 676345-33-8
(E)-Hex-2-enedioic acid 6-methyl ester 1-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl] ester

: 167304-71-4
(R)-2-Oxo-5-phenyl-cyclopentanecarboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Guidance literature:: phenyllithium; With tributylphosphine; boron trifluoride diethyl etherate; copper(l) cyanide; In diethyl ether; at -80 ℃;

(E)-Hex-2-enedioic acid 6-methyl ester 1-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl] ester; In diethyl ether; at -80 - 20 ℃; for 18h;
DOI:10.1055/s-2003-45008

Reference yield:

: 71804-27-8
(1R,2S,5R)-(+)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl chloroacetate

: 167304-71-4
(R)-2-Oxo-5-phenyl-cyclopentanecarboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 87 percent / NaH

2.1: copper(I) cyanide; n-Bu₃P; BF₃*Et₂O / diethyl ether / -80 °C

2.2: 67 percent / diethyl ether / 18 h / -80 - 20 °C

With tributylphosphine; boron trifluoride diethyl etherate; copper(l) cyanide; sodium hydride; In diethyl ether; 1.1: Michael-Arbuzov reaction / 2.2: Wittig-Horner reaction;
DOI:10.1055/s-2003-45008

Reference yield:

: 155795-48-5
(diethoxyphosphoryl)acetic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester

: 167304-71-4
(R)-2-Oxo-5-phenyl-cyclopentanecarboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 87 percent / NaH

2.1: copper(I) cyanide; n-Bu₃P; BF₃*Et₂O / diethyl ether / -80 °C

2.2: 67 percent / diethyl ether / 18 h / -80 - 20 °C

With tributylphosphine; boron trifluoride diethyl etherate; copper(l) cyanide; sodium hydride; In diethyl ether; 1.2: Wittig-Horner reaction;
DOI:10.1055/s-2003-45008