cis-1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-2-piperidinecarboxamide

Base Information

Chemical Name:cis-1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-2-piperidinecarboxamide
CAS No.:138155-20-1
Molecular Formula:C₁₉H₂₅Cl₂N₃O₂
Molecular Weight:398.332
Hs Code.:

Synonyms:cis-1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-2-piperidinecarboxamide

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Chemical Property of cis-1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-2-piperidinecarboxamide

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Technology Process of cis-1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-2-piperidinecarboxamide

There total 5 articles about cis-1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-2-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 125104-88-3,138155-17-6,138155-18-7
cis-methyl 1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-2-piperidinecarboxylate

: 138155-20-1
cis-1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-2-piperidinecarboxamide

Guidance literature:: With ammonia; at 90 ℃; for 20h;
DOI:10.1021/jm00081a009

Reference yield:

: 13602-11-4
6-methylpicolinic acid methyl ester

: 138155-20-1
cis-1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-2-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: NBS, (PhCO₂)2 / CCl₄ / 24 h / Irradiation

2: CCl₄; CH₂Cl₂ / Ambient temperature

3: 49 percent / H₂, AcOH / PtO₂ / 4 h / 760 Torr / Ambient temperature

4: 1.) 1,1'-carbonyldiimidazole / 1.) CH₂Cl₂, RT, 1.5 h, 2.) CH₂Cl₂, RT, 72 h

5: 26 percent / liquid ammonia / 20 h / 90 °C

With N-Bromosuccinimide; ammonia; hydrogen; acetic acid; 1,1'-carbonyldiimidazole; dibenzoyl peroxide; platinum(IV) oxide; In tetrachloromethane; dichloromethane;
DOI:10.1021/jm00081a009

Reference yield:

: 146462-25-1
methyl 6-(bromomethyl)picolinate

: 138155-20-1
cis-1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-2-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: CCl₄; CH₂Cl₂ / Ambient temperature

2: 49 percent / H₂, AcOH / PtO₂ / 4 h / 760 Torr / Ambient temperature

3: 1.) 1,1'-carbonyldiimidazole / 1.) CH₂Cl₂, RT, 1.5 h, 2.) CH₂Cl₂, RT, 72 h

4: 26 percent / liquid ammonia / 20 h / 90 °C

With ammonia; hydrogen; acetic acid; 1,1'-carbonyldiimidazole; platinum(IV) oxide; In tetrachloromethane; dichloromethane;
DOI:10.1021/jm00081a009