1-[6-(tert-Butyldiphenylsilanoxymethyl)-2-phenylpyrimidin-4-yl]ethanone

Base Information

Chemical Name:1-[6-(tert-Butyldiphenylsilanoxymethyl)-2-phenylpyrimidin-4-yl]ethanone
CAS No.:325685-66-3
Molecular Formula:C₂₉H₃₀N₂O₂Si
Molecular Weight:466.655
Hs Code.:

Synonyms:1-[6-(tert-Butyldiphenylsilanoxymethyl)-2-phenylpyrimidin-4-yl]ethanone

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Chemical Property of 1-[6-(tert-Butyldiphenylsilanoxymethyl)-2-phenylpyrimidin-4-yl]ethanone

Chemical Property:

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Technology Process of 1-[6-(tert-Butyldiphenylsilanoxymethyl)-2-phenylpyrimidin-4-yl]ethanone

There total 6 articles about 1-[6-(tert-Butyldiphenylsilanoxymethyl)-2-phenylpyrimidin-4-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(tert-butyl-diphenyl-silanyloxymethyl)-6-(1-ethoxy-vinyl)-2-phenyl-pyrimidine

: 325685-66-3
1-[6-(tert-Butyldiphenylsilanoxymethyl)-2-phenylpyrimidin-4-yl]ethanone

Guidance literature:: With hydrogenchloride; In acetone; at 20 ℃;
DOI:10.1002/1521-3765(20001117)6:22<4124::AID-CHEM4124>3.0.CO;2-M

Reference yield:

: 127958-19-4
4-(methoxymethyl)-2-phenylpyrimidine

: 325685-66-3
1-[6-(tert-Butyldiphenylsilanoxymethyl)-2-phenylpyrimidin-4-yl]ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: 29.0 g / POCl₃ / 3 h / Heating

2.1: BBr₃ / CH₂Cl₂ / 3 h / -12 - 0 °C

2.2: 99 percent / H₂O / diethyl ether; CH₂Cl₂ / 2 h / 20 °C

3.1: 100 percent / imidazole; DMAP / CH₂Cl₂ / 24 h / 20 °C

4.1: Pd(PPh₃)2Cl₂ / dimethylformamide / 18 h / 80 °C

4.2: aq. KF / diethyl ether; dimethylformamide / 0.75 h / 20 °C

5.1: 14.94 g / aq. HCl / acetone / 20 °C

With 1H-imidazole; hydrogenchloride; dmap; boron tribromide; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; N,N-dimethyl-formamide; acetone; 4.1: Stille coupling;
DOI:10.1002/1521-3765(20001117)6:22<4124::AID-CHEM4124>3.0.CO;2-M

Reference yield:

: 1670-14-0
benzamidine monohydrochloride

: 325685-66-3
1-[6-(tert-Butyldiphenylsilanoxymethyl)-2-phenylpyrimidin-4-yl]ethanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaOMe / methanol; ethanol / 21 h / Heating

2.1: 29.0 g / POCl₃ / 3 h / Heating

3.1: BBr₃ / CH₂Cl₂ / 3 h / -12 - 0 °C

3.2: 99 percent / H₂O / diethyl ether; CH₂Cl₂ / 2 h / 20 °C

4.1: 100 percent / imidazole; DMAP / CH₂Cl₂ / 24 h / 20 °C

5.1: Pd(PPh₃)2Cl₂ / dimethylformamide / 18 h / 80 °C

5.2: aq. KF / diethyl ether; dimethylformamide / 0.75 h / 20 °C

6.1: 14.94 g / aq. HCl / acetone / 20 °C

With 1H-imidazole; hydrogenchloride; dmap; sodium methylate; boron tribromide; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; 5.1: Stille coupling;
DOI:10.1002/1521-3765(20001117)6:22<4124::AID-CHEM4124>3.0.CO;2-M