3-[trans-2-(2-methoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide

Base Information

Chemical Name:3-[trans-2-(2-methoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide
CAS No.:1282520-13-1
Molecular Formula:C₂₃H₂₃FN₂O₄S
Molecular Weight:442.511
Hs Code.:

Synonyms:3-[trans-2-(2-methoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide

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Chemical Property of 3-[trans-2-(2-methoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide

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Technology Process of 3-[trans-2-(2-methoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide

There total 8 articles about 3-[trans-2-(2-methoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.9%

: 64588-82-5
5-fluoro-1,3-thiazol-2-amine

: 1282521-24-7
3-[trans-2-(2-methoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid

: 1282520-13-1
3-[trans-2-(2-methoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide

Guidance literature:: 5-fluoro-1,3-thiazol-2-amine; 3-[trans-2-(2-methoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 12h;

With hydrogenchloride; In dichloromethane; water;

Reference yield:

: 13036-02-7
Dimethyl 5-hydroxyisophthalate

: 1282520-13-1
3-[trans-2-(2-methoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C

2.1: potassium hydroxide; methanol / 12 h / 100 °C

3.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C

3.2: 3 h / 0 °C

4.1: tribromide phosphate / tetrahydrofuran / 12 h / 0 - 20 °C

5.1: 3 h / 160 °C

6.1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

7.1: potassium hydroxide / 18-crown-6 ether / dichloromethane / 20 h / 20 °C

8.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

With methanol; borane-THF; di-isopropyl azodicarboxylate; tribromide phosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; potassium hydroxide; sodium hydroxide; 18-crown-6 ether; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1282520-89-1
5-(2-methoxy-(1S)-methyl-ethoxy)isophthalic acid dimethyl ester

: 1282520-13-1
3-[trans-2-(2-methoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide; methanol / 12 h / 100 °C

2.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C

2.2: 3 h / 0 °C

3.1: tribromo phosphate / tetrahydrofuran / 12 h / 0 - 20 °C

4.1: 3 h / 160 °C

5.1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

6.1: potassium hydroxide / 18-crown-6 ether / dichloromethane / 20 h / 20 °C

7.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

With methanol; borane-THF; tribromo phosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; sodium hydroxide; 18-crown-6 ether; In tetrahydrofuran; dichloromethane;