methyl 2-acetamido-3-[2-[2-[4-(pyrrolidine-1-carbonyl)benzoylamino]ethoxy]-4-cyanophenyl]acrylate

Base Information

Chemical Name:methyl 2-acetamido-3-[2-[2-[4-(pyrrolidine-1-carbonyl)benzoylamino]ethoxy]-4-cyanophenyl]acrylate
CAS No.:538335-93-2
Molecular Formula:C₂₇H₂₈N₄O₆
Molecular Weight:504.543
Hs Code.:

Synonyms:methyl 2-acetamido-3-[2-[2-[4-(pyrrolidine-1-carbonyl)benzoylamino]ethoxy]-4-cyanophenyl]acrylate

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Chemical Property of methyl 2-acetamido-3-[2-[2-[4-(pyrrolidine-1-carbonyl)benzoylamino]ethoxy]-4-cyanophenyl]acrylate

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Technology Process of methyl 2-acetamido-3-[2-[2-[4-(pyrrolidine-1-carbonyl)benzoylamino]ethoxy]-4-cyanophenyl]acrylate

There total 9 articles about methyl 2-acetamido-3-[2-[2-[4-(pyrrolidine-1-carbonyl)benzoylamino]ethoxy]-4-cyanophenyl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 150057-97-9
4-(pyrrolidine-1-carbonyl)benzoic acid

: 3-[4-cyano-2-(2-aminoethoxy)phenyl]-2-acetamidoacrylic acid methyl ester hydrochloride

: 538335-93-2
methyl 2-acetamido-3-[2-[2-[4-(pyrrolidine-1-carbonyl)benzoylamino]ethoxy]-4-cyanophenyl]acrylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm020485x

Reference yield:

: 7377-26-6
4-Methoxycarbonylbenzoyl chloride

: 538335-93-2
methyl 2-acetamido-3-[2-[2-[4-(pyrrolidine-1-carbonyl)benzoylamino]ethoxy]-4-cyanophenyl]acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / CH₂Cl₂

2: 23.7 g / aq. NaOH / methanol; tetrahydrofuran

3: 50 percent / triethylamine; 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide

With sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020485x

Reference yield:

: 210962-75-7
3-hydroxy-4-iodobenzonitrile

: 538335-93-2
methyl 2-acetamido-3-[2-[2-[4-(pyrrolidine-1-carbonyl)benzoylamino]ethoxy]-4-cyanophenyl]acrylate

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / K₂CO₃; KI / dimethylformamide / 60 °C

2: 60 percent / triethylamine; tri-o-tolylphosphine; Pd(OAc)2 / acetonitrile / Heating

3: 78 percent / HCl / dioxane

4: 50 percent / triethylamine; 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide

With hydrogenchloride; palladium diacetate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tris-(o-tolyl)phosphine; potassium iodide; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile; 2: Heck reaction;
DOI:10.1021/jm020485x