(R_s)-2-methyl-N-[(S)-1-(2-vinylphenyl)but-3-en-1-yl]propane-2-sulfinamide

Base Information

Chemical Name:(R_s)-2-methyl-N-[(S)-1-(2-vinylphenyl)but-3-en-1-yl]propane-2-sulfinamide
CAS No.:1446434-04-3
Molecular Formula:C₁₆H₂₃NOS
Molecular Weight:277.431
Hs Code.:

(R<sub>s</sub>)-2-methyl-N-[(S)-1-(2-vinylphenyl)but-3-en-1-yl]propane-2-sulfinamide

Synonyms:(R_s)-2-methyl-N-[(S)-1-(2-vinylphenyl)but-3-en-1-yl]propane-2-sulfinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R_s)-2-methyl-N-[(S)-1-(2-vinylphenyl)but-3-en-1-yl]propane-2-sulfinamide

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Technology Process of (R_s)-2-methyl-N-[(S)-1-(2-vinylphenyl)but-3-en-1-yl]propane-2-sulfinamide

There total 3 articles about (R_s)-2-methyl-N-[(S)-1-(2-vinylphenyl)but-3-en-1-yl]propane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1446433-95-9
(R_s,E)-2-methyl-N-(2-vinylbenzylidene)propane-2-sulfinamide

: 106-95-6
allyl bromide

: 1446434-04-3
(R_s)-2-methyl-N-[(S)-1-(2-vinylphenyl)but-3-en-1-yl]propane-2-sulfinamide

Guidance literature:: allyl bromide; With zinc; In tetrahydrofuran; at -55 ℃; Inert atmosphere;

(R_s,E)-2-methyl-N-(2-vinylbenzylidene)propane-2-sulfinamide; In tetrahydrofuran; at -55 ℃; for 3h; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol4017113

Reference yield:

: C₁₃H₁₇NOS

: 106-95-6
allyl bromide

: 1446434-04-3
(R_s)-2-methyl-N-[(S)-1-(2-vinylphenyl)but-3-en-1-yl]propane-2-sulfinamide

Guidance literature:: allyl bromide; With zinc; In tetrahydrofuran; at 55 ℃; Inert atmosphere;

C₁₃H₁₇NOS; In tetrahydrofuran; at -40 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/acs.orglett.5b03671

Reference yield:

: 28272-96-0
2-vinylbenzaldehyde

: 1446434-04-3
(R_s)-2-methyl-N-[(S)-1-(2-vinylphenyl)but-3-en-1-yl]propane-2-sulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: titanium(IV) tetraethanolate / dichloromethane / 12 h / 20 °C / Inert atmosphere

2.1: zinc / tetrahydrofuran / -55 °C / Inert atmosphere

2.2: 3 h / -55 °C / Inert atmosphere

With titanium(IV) tetraethanolate; zinc; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol4017113